SCHEDULE 13G

Amendment No. 0 
PTC THERAPEUTICS INC 
Common Stock 
Cusip #69366J200 


Cusip #69366J200 
Item 1:	Reporting Person - FMR LLC
Item 4:	Delaware
Item 5:	0 
Item 6:	0 
Item 7:	2,044,518 
Item 8:	0 
Item 9:	2,044,518 
Item 11:	8.205% 
Item 12:	    HC


Cusip #69366J200  
Item 1:	Reporting Person - Edward C. Johnson 3d 
Item 4:	United States of America
Item 5:	0 
Item 6:	0 
Item 7:	2,044,518 
Item 8:	0 
Item 9:	2,044,518 
Item 11:	8.205% 
Item 12:	IN 




	SCHEDULE 13G - TO BE INCLUDED IN 
STATEMENTS
	FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)



Item 1(a).	Name of Issuer:	

		PTC THERAPEUTICS INC 

Item 1(b).	Name of Issuer's Principal Executive Offices:

		100 CORPORATE COURT  
		SOUTH PLAINFIELD, NJ  07080-
2449
		  

Item 2(a).	Name of Person Filing: 

		FMR LLC

Item 2(b).	Address or Principal Business Office or, if None, 
Residence:

		245 Summer Street, Boston, 
Massachusetts  02210

Item 2(c).	Citizenship:

		Not applicable

Item 2(d).	Title of Class of Securities:

		Common Stock 

Item 2(e).	CUSIP Number:  

		69366J200 

Item 3.	This statement is filed pursuant to Rule 13d-1(b) or 13d-2(b) 
and the person filing, FMR LLC, is a parent holding company 
in accordance with Section 240.13d-1(b)(ii)(G).  (Note:  See 
Item 7).

Item 4.	Ownership

	(a)	Amount Beneficially Owned:	2,044,518 

	(b)	Percent of Class:	8.205% 

	(c)	Number of shares as to which such 
person has:  

	(i)	sole power to vote or to direct 
the vote:	0 

	(ii)	shared power to vote or to 
direct the vote:	0 

	(iii)	sole power to dispose or to 
direct the disposition of:	2,044,518 

	(iv)	shared power to dispose or to 
direct the disposition of:	0 



Item 5.	Ownership of Five Percent or Less of a Class.

	Not applicable.

Item 6.	Ownership of More than Five Percent on Behalf of Another 
Person.

	Various persons have the right to receive or the power to 
direct the receipt of dividends from, or the proceeds from the 
sale of, the Common Stock of PTC THERAPEUTICS INC.  
No one person's interest in the Common Stock of PTC 
THERAPEUTICS INC is more than five percent of the total 
outstanding Common Stock.

Item 7.	Identification and Classification of the Subsidiary Which 
Acquired the Security Being Reported on By the Parent 
Holding Company.

	See attached Exhibit A. 

Item 8.	Identification and Classification of Members of 
the Group.

	Not applicable.  See attached Exhibit A. 

Item 9.	Notice of Dissolution of Group.

	Not applicable.

Item 10.	Certification.  

	By signing below I certify that, to the best of my knowledge 
and belief, the securities referred to above were acquired in the 
ordinary course of business and were not acquired for the 
purpose of and do not have the effect of changing or 
influencing the control of the issuer of such securities and 
were not acquired in connection with or as a participant in any 
transaction having such purpose or effect.     

Signature

	After reasonable inquiry and to the best of my knowledge and 
belief, I certify that the information set forth in this statement 
is true, complete and correct. 

February 13, 2014 			
Date

 /s/ Scott C. Goebel			
Signature

Scott C. Goebel				
Duly authorized under Power of Attorney
effective as of June 1, 2008 by and on behalf of FMR LLC 
and its direct and indirect  subsidiaries


	SCHEDULE 13G - TO BE INCLUDED IN 
STATEMENTS
	FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)



	Pursuant to the instructions in Item 7 of Schedule 13G, 
Fidelity Management & Research Company ("Fidelity"), 245 
Summer Street, Boston, Massachusetts 02210, a wholly-
owned subsidiary of FMR LLC and an investment adviser 
registered under Section 203 of the Investment Advisers Act 
of 1940, is the beneficial owner of 153,200 shares or 0.615% 
of the Common Stock outstanding of PTC THERAPEUTICS 
INC  ("the Company") as a result of acting as investment 
adviser to various investment companies registered under 
Section 8 of the Investment Company Act of 1940.

	Edward C. Johnson 3d and FMR LLC, through its 
control of Fidelity, and the funds each has sole power to 
dispose of the 153,200 shares owned by the Funds.

	Fidelity SelectCo, LLC ("SelectCo"), 1225 17th Street, 
Suite 1100, Denver, Colorado 80202, a wholly-owned 
subsidiary of FMR LLC and an investment adviser registered 
under Section 203 of the Investment Advisers Act of 1940, is 
the beneficial owner of 1,891,318 shares or 7.590% of the 
Common Stock outstanding of PTC THERAPEUTICS INC 
("the Company") as a result of acting as investment adviser to 
various investment companies registered under Section 8 of 
the Investment Company Act of 1940 (the "SelectCo Funds").

	Edward C. Johnson 3d and FMR LLC, through its 
control of SelectCo, and the SelectCo Funds each has sole 
power to dispose of the 1,891,318 owned by the SelectCo 
Funds.

	Members of the family of Edward C. Johnson 3d, 
Chairman of FMR LLC, are the predominant owners, directly 
or through trusts, of Series B voting common shares of FMR 
LLC, representing 49% of the voting power of FMR LLC.  
The Johnson family group and all other Series B shareholders 
have entered into a shareholders' voting agreement under 
which all Series B voting common shares will be voted in 
accordance with the majority vote of Series B voting common 
shares.  Accordingly, through their ownership of voting 
common shares and the execution of the shareholders' voting 
agreement, members of the Johnson family may be deemed, 
under the Investment Company Act of 1940, to form a 
controlling group with respect to FMR LLC.

	Neither FMR LLC nor Edward C. Johnson 3d, 
Chairman of FMR LLC, has the sole power to vote or direct 
the voting of the shares owned directly by the Fidelity Funds, 
which power resides with the Funds' Boards of Trustees.  
Fidelity carries out the voting of the shares under written 
guidelines established by the Funds' Boards of Trustees.



	SCHEDULE 13G - TO BE INCLUDED IN 
STATEMENTS
	FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)
	RULE 13d-1(f)(1)  AGREEMENT

	The undersigned persons, on February 13, 2014, agree 
and consent to the joint filing on their behalf of this Schedule 
13G in connection with their beneficial ownership of the 
Common Stock of PTC THERAPEUTICS INC at December 
31, 2013.

	FMR LLC

	By /s/ Scott C. Goebel			
	Scott C. Goebel
	Duly authorized under Power of Attorney effective as 
of June 1, 2008, by and on behalf of FMR LLC and its direct 
and indirect subsidiaries

	Edward C. Johnson 3d

	By /s/ Scott C. Goebel			
	Scott C. Goebel
	Duly authorized under Power of Attorney effective as 
of June 1, 2008, by and on behalf of Edward C. Johnson 3d

	Fidelity Management & Research Company

	By /s/ Scott C. Goebel			
	Scott C. Goebel
	Senior V.P. and General Counsel