UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 13D

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 2 )*

PTC Therapeutics, Inc.

(Name of Issuer)

Common Stock, $0,001 par value per share

(Title of Class of Securities)

69366J200

(CUSIP Number)

HBM Healthcare Investments (Cayman) Ltd.

Governor Square, Suite #4-212-2

23 Lime Tree Bay Ave. West Bay

Grand Cayman, Cayman Islands

Telephone:  (345) 946-8002

(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)

October 28, 2014

(Date of Event Which Requires Filing of This Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. o

Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See §240.13d-7 for other parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

(1) This percentage is calculated based upon 33,602,541 shares of the Issuer’s Common Stock outstanding as of November 5, 2014 as reported in Issuer’s Form 10Q filed on November 6, 2014.

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Explanatory Note:  This Amendment No. 2 to Schedule 13 D (this “Amendment No. 1”) is being filed as an amendment to the initial statement on Schedule 13 D relating to the Common Stock, par value $0.001 per share, of PTC Therapeutics, Inc., a Delaware corporation (the “Issuer”), as filed with the Securities and Exchange Commission (the “SEC”) on July 5, 2013 (the “original 13D”) and amended by Amendment No. 1 filed October 27, 2014 (the “Schedule 13D”).

All capitalized terms not otherwise defined herein shall have the meaning ascribed to the terms in the Original 13D.  The Original Schedule 13 D is hereby further amended and remains in full force and effect.

Item 4.              Purpose of Transaction

The response set forth in Item 4 of Schedule 13D is hereby amended and supplemented by adding the following paragraph at the end of Item 4:

HBM sold an aggregate of 125,000 of Common Stock in open market transactions from October 27, 2014 through October 28, 2014 for gross proceeds of approximately $4,815,810.30.

Item 5.    Interest in Securities of the Issuer

(a) – (b) As of the date of this filing, HBM directly beneficially owns 1,618,717 shares of Common Stock, which constitutes approximately 4.82% of the Issuer’s Common Stock based upon 33,602,541 shares of the Issuer’s Common Stock outstanding as of November 5, 2014 as reported in Issuer’s Form 10Q filed on November 6, 2014.

(c)                       The following is a list of the shares sold in multiple open market transactions.

(d)                     Not apply.

(e)                       This statement is being filed to report that as of October 28, 2014, HBM ceased to be a beneficial owner of more than five percent of Issuer’s Common Stock.

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After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

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