Document and Entity Information Statement [Table] Statement [Line Items] Statement Entity Registrant Name Entity Central Index Key Document Type Document Period End Date Amendment Flag Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Filer Category Entity Public Float Entity Common Stock, Shares Outstanding Document Fiscal Year Focus Document Fiscal Period Focus Consolidated Balance Sheets Assets [Abstract] Assets Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents, end of period Cash and cash equivalents, beginning of period Cash and cash equivalents Marketable Securities, Current Marketable securities Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Receivables, Net, Current Trade receivables, net Assets, Current Total current assets Property, Plant and Equipment, Net Fixed assets, net Net fixed assets Property and equipment, net Represents the carrying value of amounts transferred to third parties for security purposes and other noncurrent assets that are expected to be returned or applied towards payment after one year or beyond the operating cycle, if longer. Deposits and Other Assets Noncurrent Deposits and other assets Assets Total assets Total assets Liabilities and Equity [Abstract] Liabilities and stockholders' equity Liabilities, Current [Abstract] Current liabilities: Accounts Payable and Accrued Liabilities, Current Accounts payable and accrued expenses Accounts payable and accrued expenses Deferred Revenue, Current Deferred revenue Liabilities, Current Total current liabilities Long-term Debt, Excluding Current Maturities Long-term debt Other Liabilities, Noncurrent Other long-term liabilities Liabilities Total liabilities Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Common Stock, Value, Issued Common stock, $0.001 par value. Authorized 125,000,000 shares; issued and outstanding 33,916,559 shares at December 31, 2015. Authorized 125,000,000 shares; issued and outstanding 32,898,392 shares at December 31, 2014 Additional Paid in Capital Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Balance at the end of the period Balance at the beginning of the period Accumulated other comprehensive loss Accumulated deficit. Accumulated deficit Stockholders' Equity Attributable to Parent Balance Balance Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Common Stock, Par or Stated Value Per Share Common stock, par value (in dollars per share) Common Stock, Shares Authorized Common stock, authorized shares Common Stock, Shares, Issued Common stock, issued shares Common Stock, Shares, Outstanding Common stock, outstanding shares Consolidated Statements of Operations Revenue, Net [Abstract] Revenues: Represents the amount of revenue earned from product sales during the reporting period. Net Product Sales Net product revenue Amount of revenue earned from collaborative research and development and licensing agreements and non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements. Collaboration and grant revenue Collaboration and grant revenue Revenue, Net Total revenues Operating Expenses [Abstract] Operating expenses: Research and Development Expense Research and development General and Administrative Expense Selling, general and administrative Operating Expenses Operating expenses Total operating expenses Operating Income (Loss) Loss from operations Loss from operations Interest Income (Expense), Nonoperating, Net Interest (expense) income, net Gains (Losses) on Extinguishment of Debt Loss on extinguishment of debt Loss on extinguishment of debt Other Nonoperating Income (Expense) Other (expense) income, net Loss before income tax expense Loss from operations before tax (expense) benefit Income Tax Expense (Benefit) Income tax (expense) benefit Net Income (Loss) Attributable to Parent Net loss Net loss Represents the capital gains taxes paid by the entity on behalf of the shareholders. Deemed Dividend Deemed dividend Deemed dividend Preferred Stock Redemption Discount Gain on exchange of convertible preferred stock in connection with recapitalization Gain on extinguishment of shares of Series One, Two and Three stock Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net loss attributable to common stockholders Weighted Average Number of Shares Outstanding, Diluted [Abstract] Weighted-average shares outstanding: Denominator Weighted Average Number of Shares Outstanding, Basic and Diluted Denominator for basic and diluted net loss per share (in shares) Basic and diluted (in shares) Earnings per share Net loss per share-basic and diluted (in dollars per share) Earnings Per Share, Basic and Diluted Basic and diluted (in dollars per share) Net loss per share-basic and diluted (in dollars per share) Consolidated Statements of Comprehensive Loss Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive loss: Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Unrealized (loss)/gain on marketable securities Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent Foreign currency translation loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Consolidated Statements of Convertible Preferred Stock and Changes in Stockholders' Equity (Deficit) Class of Stock [Axis] Class Of Stock [Domain] Class of Stock [Domain] Represents series one to three preferred stock that may be exchanged into common shares or other types of securities at the owner's option. Series One To Three Convertible Preferred Stock [Member] Series One-Three convertible preferred stock Represents outstanding nonredeemable series four senior preferred stock. Series Four Senior Preferred Stock [Member] Series Four convertible preferred stock Represents outstanding nonredeemable series five junior preferred stock. Series Five Junior Preferred Stock [Member] Series Five convertible preferred stock Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Common Stock [Member] Common stock Additional Paid In Capital [Member] Additional paid-in capital Accumulated Other Comprehensive Income [Member] Accumulated other comprehensive income (loss) Retained Earnings [Member] Accumulated deficit Increase (Decrease) in Temporary Equity [Roll Forward] Increase (decrease) in temporary equity Temporary Equity, Carrying Amount, Attributable to Parent Balance, end of period Balance, beginning of period Temporary Equity, Shares Issued Balance, end of period (in shares) Balance, beginning of period (in shares) The gross value of temporary equity converted and reissued during the period upon the exchange of convertible securities. Temporary Equity Converted Issued During Period Value Exchange of Convertible Securities Issuance and exchange of series of convertible preferred stock for series of convertible preferred stock Number of temporary shares converted and reissued during the period as a result of the conversion of convertible securities. Temporary Equity Converted Issued, During Period Shares Exchange of Convertible Securities Issuance and exchange of series of convertible preferred stock for series of convertible preferred stock (in shares) Temporary Equity, Elimination as Part of Reorganization Conversion of series of convertible preferred stock to common stock Conversion of Stock, Shares Converted Conversion of series of convertible preferred stock to common stock (in shares) Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity Shares, Issued Balance (in shares) Balance (in shares) Stock Issued During Period, Shares, Reverse Stock Splits Reverse stock split In the absence of retained earnings, the adjustment to additional paid in capital for the decrease in carrying amount of redeemable preferred stock that is classified as temporary equity. Adjustments to Additional Paid in Capital Decrease in Carrying Amount of Redeemable Preferred Stock Issuance and exchange of series of convertible preferred stock for series of convertible preferred stock Stock Issued During Period, Value, New Issues Aggregate purchase price Issuance of common stock from IPO and exercise of over allotment exercise, net of offering costs Stock Issued During Period, Shares, New Issues Shares issued and sold Issuance of common stock from IPO and exercise of over allotment exercise, net of offering costs (in shares) Issuance of common stock from public offerings and exercise of over allotment exercise, net of offering costs. Stock Issued During Period Value New Issues Including Public Offerings Issuance of common stock from public offerings and exercise of over allotment exercise, net of offering costs Number of new stock issued during the period including public offerings. Stock Issued During Period Shares New Issues Including Public Offerings Issuance of common stock from public offerings and exercise of over allotment exercise, net of offering costs (in shares) Stock Issued During Period, Value, Conversion of Convertible Securities Conversion of series of convertible preferred stock to common stock Stock Issued During Period, Shares, Conversion of Convertible Securities Conversion of series of convertible preferred stock to common stock (in shares) Adjustments to Additional Paid in Capital, Equity Component of Convertible Debt Equity component of the convertible notes issuance, net Debt Issuance Cost Debt Issuance Cost Stock Issued During Period, Value, Stock Options Exercised Exercise of stock options Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Exercised (in shares) Exercise of stock options (in shares) Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Restricted stock vesting Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Restricted stock vesting (in shares) Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Share-based compensation expense Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Comprehensive income (loss) Consolidated Statements of Cash Flows Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Cash flows from operating activities Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Depreciation Depreciation Depreciation expense Fair Value Adjustment of Warrants Change in valuation of warrant liability Accretion (Amortization) of Discounts and Premiums, Investments Amortization of premiums on investments Amortization of Financing Costs Amortization of debt issuance costs Share-based Compensation Share-based compensation expense Paid-in-Kind Interest Non-cash interest expense Gain (Loss) on Disposition of Assets Disposal of asset Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other current assets Increase (Decrease) in Receivables Trade receivables, net Increase (Decrease) in Deposit Assets Deposits and other assets Increase (Decrease) in Accounts Payable and Accrued Liabilities Accounts payable and accrued expenses Increase (Decrease) in Other Noncurrent Liabilities Other long-term liabilities Increase (Decrease) in Deferred Revenue Deferred revenue Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Cash flows from investing activities Payments to Acquire Property, Plant, and Equipment Purchases of fixed assets Payments to Acquire Marketable Securities Purchases of marketable securities Proceeds from Sale and Maturity of Marketable Securities Sale & redemptions of marketable securities Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash used in investing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Cash flows from financing activities Repayments of Long-term Debt Payments on long-term debt Sale of Stock, Consideration Received on Transaction Net proceeds from sale of Series Four preferred stock Proceeds from Stock Options Exercised Proceeds from exercise of options Proceeds from Issuance of Common Stock Net proceeds from public offerings Payments of Debt Issuance Costs Debt issuance costs related to convertible notes Proceeds from Convertible Debt Proceeds from issuance of convertible notes Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash provided by financing activities Effect of Exchange Rate on Cash Effect of exchange rate changes on cash Net Cash Provided by (Used in) Continuing Operations Net increase in cash and cash equivalents Supplemental Cash Flow Information [Abstract] Supplemental disclosure of cash information Interest Paid Cash paid for interest Income Taxes Paid, Net Cash paid for income taxes Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Supplemental disclosures of non-cash information related to investing and financing activities Represents change in the unrealized gain (loss) on marketable securities in noncash investing and financing activities. Change in Unrealized Gain (Loss) on Marketable Securities Change in unrealized (loss) gain on marketable securities Represents change in the carrying value of preferred securities resulting from recapitalization in a noncash financing activity. Change in Carrying Value of Preferred Securities Resulting from Recapitalization Change in carry value of preferred securities resulting from recapitalization The Company Nature of Operations [Text Block] The Company Summary of significant accounting policies Basis of Presentation and Significant Accounting Policies [Text Block] Summary of significant accounting policies Fair value of financial instruments and investments Fair Value Disclosures [Text Block] Fair value of financial instruments and investments Fixed assets Property, Plant and Equipment Disclosure [Text Block] Fixed assets Accounts payable and accrued expenses Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Accounts payable and accrued expenses Long-term debt. Debt and Capital Leases Disclosures [Text Block] Long-term debt Capital structure Stockholders' Equity Note Disclosure [Text Block] Capital structure Earnings Per Share [Text Block] Earnings per share Stock award plan Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock award plan Other comprehensive income (loss) and accumulated other comprehensive items Comprehensive Income (Loss) Note [Text Block] Other comprehensive income (loss) and accumulated other comprehensive items Collaborations and grants Collaborative Arrangement Disclosure [Text Block] Collaborations and grants Income taxes Income Tax Disclosure [Text Block] Income taxes Commitments and contingencies Commitments and Contingencies Disclosure [Text Block] Commitments and contingencies Geographic information Revenues from External Customers and Long-Lived Assets Revenues from External Customers and Long-Lived Assets Segment Reporting Disclosure [Text Block] Geographic information 401(k) plan Compensation and Employee Benefit Plans, Other than Share-based Compensation [Text Block] 401(k) plan Subsequent events Subsequent Events [Text Block] Subsequent events Selected quarterly financial data (Unaudited) Quarterly Financial Information [Text Block] Selected quarterly financial data (Unaudited) Basis of Accounting, Policy [Policy Text Block] Basis of presentation Use of Estimates, Policy [Policy Text Block] Use of estimates Consolidation, Policy [Policy Text Block] Consolidation Segment Reporting, Policy [Policy Text Block] Segment and geographic information Cash and Cash Equivalents, Policy [Policy Text Block] Cash equivalents Marketable Securities, Policy [Policy Text Block] Marketable securities Property, Plant and Equipment, Policy [Policy Text Block] Fixed assets Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of credit risk Disclosure of accounting policy for inventories and cost of revenue. Inventories And Cost Of Revenue Policy Text Block Inventories and cost of product revenue Deferred Charges, Policy [Policy Text Block] Deferred rent Comprehensive Income, Policy [Policy Text Block] Accumulated other comprehensive income (loss) Revenue Recognition, Policy [Policy Text Block] Revenue recognition