00100 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 00200 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 00300 - Statement - Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 00500 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 40302 - Disclosure - Fair value of financial instruments and marketable securities (Details 2) link:presentationLink link:calculationLink link:definitionLink 40401 - Disclosure - Fixed assets (Details) link:presentationLink link:calculationLink link:definitionLink 40501 - Disclosure - Accounts payable and accrued expenses (Details) link:presentationLink link:calculationLink link:definitionLink 40602 - Disclosure - Long-term debt, 2015 Convertible Notes (Details 2) link:presentationLink link:calculationLink link:definitionLink 40801 - Disclosure - Earnings per share (Details) link:presentationLink link:calculationLink link:definitionLink 41201 - Disclosure - Income taxes (Details) link:presentationLink link:calculationLink link:definitionLink 41301 - Disclosure - Commitments and contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 00090 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 00105 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 00400 - Statement - Consolidated Statements of Convertible Preferred Stock and Changes in Stockholders' Equity (Deficit) link:presentationLink link:calculationLink link:definitionLink 10101 - Disclosure - The Company link:presentationLink link:calculationLink link:definitionLink 10201 - Disclosure - Summary of significant accounting policies link:presentationLink link:calculationLink link:definitionLink 10301 - Disclosure - Fair value of financial instruments and investments link:presentationLink link:calculationLink link:definitionLink 10401 - Disclosure - Fixed assets link:presentationLink link:calculationLink link:definitionLink 10501 - Disclosure - Accounts payable and accrued expenses link:presentationLink link:calculationLink link:definitionLink 10601 - Disclosure - Long-term debt link:presentationLink link:calculationLink link:definitionLink 10701 - Disclosure - Capital structure link:presentationLink link:calculationLink link:definitionLink 10801 - Disclosure - Earnings per share link:presentationLink link:calculationLink link:definitionLink 10901 - Disclosure - Stock award plan link:presentationLink link:calculationLink link:definitionLink 11001 - Disclosure - Other comprehensive income (loss) and accumulated other comprehensive items link:presentationLink link:calculationLink link:definitionLink 11101 - Disclosure - Collaborations and grants link:presentationLink link:calculationLink link:definitionLink 11201 - Disclosure - Income taxes link:presentationLink link:calculationLink link:definitionLink 11301 - Disclosure - Commitments and contingencies link:presentationLink link:calculationLink link:definitionLink 11401 - Disclosure - Geographic information link:presentationLink link:calculationLink link:definitionLink 11501 - Disclosure - 401(k) plan link:presentationLink link:calculationLink link:definitionLink 11601 - Disclosure - Subsequent events link:presentationLink link:calculationLink link:definitionLink 11701 - Disclosure - Selected quarterly financial data (Unaudited) link:presentationLink link:calculationLink link:definitionLink 20202 - Disclosure - Summary of significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 30203 - Disclosure - Summary of significant accounting policies (Tables) link:presentationLink link:calculationLink link:definitionLink 30303 - Disclosure - Fair value of financial instruments and investments (Tables) link:presentationLink link:calculationLink link:definitionLink 30403 - Disclosure - Fixed assets (Tables) link:presentationLink link:calculationLink link:definitionLink 30503 - Disclosure - Accounts payable and accrued expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 30603 - Disclosure - Long-term Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 30703 - Disclosure - Capital structure (Tables) link:presentationLink link:calculationLink link:definitionLink 30803 - Disclosure - Earnings per share (Tables) link:presentationLink link:calculationLink link:definitionLink 30903 - Disclosure - Stock award plan (Tables) link:presentationLink link:calculationLink link:definitionLink 31003 - Disclosure - Other comprehensive income (loss) and accumulated other comprehensive items (Tables) link:presentationLink link:calculationLink link:definitionLink 31203 - Disclosure - Income taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 31303 - Disclosure - Commitments and contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 31403 - Disclosure - Geographic information (Tables) link:presentationLink link:calculationLink link:definitionLink 31703 - Disclosure - Selected quarterly financial data (Tables) link:presentationLink link:calculationLink link:definitionLink 40101 - Disclosure - The Company (Detail) link:presentationLink link:calculationLink link:definitionLink 40201 - Disclosure - Summary of significant accounting policies (Detail) link:presentationLink link:calculationLink link:definitionLink 40202 - Disclosure - Summary of significant accounting policies (Details 2) link:presentationLink link:calculationLink link:definitionLink 40301 - Disclosure - Fair value of financial instruments and marketable securities (Details) link:presentationLink link:calculationLink link:definitionLink 40303 - Disclosure - Fair value of financial instruments and marketable securities (Details 3) link:presentationLink link:calculationLink link:definitionLink 40304 - Disclosure - Fair value of financial instruments and marketable securities (Details 4) link:presentationLink link:calculationLink link:definitionLink 40601 - Disclosure - Long-term debt (Details) link:presentationLink link:calculationLink link:definitionLink 40701 - Disclosure - Capital structure (Details) link:presentationLink link:calculationLink link:definitionLink 40702 - Disclosure - Capital structure (Details 2) link:presentationLink link:calculationLink link:definitionLink 40703 - Disclosure - Capital structure (Details 3) link:presentationLink link:calculationLink link:definitionLink 40901 - Disclosure - Stock award plan (Details) link:presentationLink link:calculationLink link:definitionLink 40902 - Disclosure - Stock option plan (Details 2) link:presentationLink link:calculationLink link:definitionLink 40903 - Disclosure - Stock award plan (Details 3) link:presentationLink link:calculationLink link:definitionLink 41001 - Disclosure - Other comprehensive income (loss) and accumulated other comprehensive items (Details) link:presentationLink link:calculationLink link:definitionLink 41101 - Disclosure - Collaborations and grants (Details) link:presentationLink link:calculationLink link:definitionLink 41202 - Disclosure - Income taxes (Details 2) link:presentationLink link:calculationLink link:definitionLink 41203 - Disclosure - Income taxes (Details 3) link:presentationLink link:calculationLink link:definitionLink 41204 - Disclosure - Income taxes (Details 4) link:presentationLink link:calculationLink link:definitionLink 41401 - Disclosure - Geographic information (Details) link:presentationLink link:calculationLink link:definitionLink 41501 - Disclosure - 401(k) plan (Details) link:presentationLink link:calculationLink link:definitionLink 41701 - Disclosure - Selected quarterly financial data (Details) link:presentationLink link:calculationLink link:definitionLink