2117100 - Disclosure - 401(k) plan link:presentationLink link:calculationLink link:definitionLink 2417401 - Disclosure - 401(k) plan (Details) link:presentationLink link:calculationLink link:definitionLink 2105100 - Disclosure - Accounts payable and accrued expenses link:presentationLink link:calculationLink link:definitionLink 2405402 - Disclosure - Accounts payable and accrued expenses (Details) link:presentationLink link:calculationLink link:definitionLink 2305301 - Disclosure - Accounts payable and accrued expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 2101100 - Disclosure - Acquisitions link:presentationLink link:calculationLink link:definitionLink 2401405 - Disclosure - Acquisitions -Business Acquisition, Pro Forma Information (Details) link:presentationLink link:calculationLink link:definitionLink 2401402 - Disclosure - Acquisitions - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2401403 - Disclosure - Acquisitions - Preliminary Allocation of purchase price (Details) link:presentationLink link:calculationLink link:definitionLink 2401404 - Disclosure - Acquisitions -Schedule of Business Acquisitions (Details) link:presentationLink link:calculationLink link:definitionLink 2401406 - Disclosure - Acquisitions - Schedule of purchase price (Details) link:presentationLink link:calculationLink link:definitionLink 2301301 - Disclosure - Acquisitions (Tables) link:presentationLink link:calculationLink link:definitionLink 2401407 - Disclosure - Acquisitions - Total Purchase Consideration (Details) link:presentationLink link:calculationLink link:definitionLink 2107100 - Disclosure - Capital structure link:presentationLink link:calculationLink link:definitionLink 2407402 - Disclosure - Capital structure - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2407403 - Disclosure - Capital structure - Summary of Warrants (Details) link:presentationLink link:calculationLink link:definitionLink 2307301 - Disclosure - Capital structure (Tables) link:presentationLink link:calculationLink link:definitionLink 2115100 - Disclosure - Commitments and contingencies link:presentationLink link:calculationLink link:definitionLink 2415403 - Disclosure - Commitments and contingencies - Lease, Operating Leases, Future Lease Payments (Details) link:presentationLink link:calculationLink link:definitionLink 2415402 - Disclosure - Commitments and contingencies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2315301 - Disclosure - Commitments and contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 2101100 - Disclosure - The Company link:presentationLink link:calculationLink link:definitionLink 2401401 - Disclosure - The Company (Details) link:presentationLink link:calculationLink link:definitionLink 1001000 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 1001501 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 1005000 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 1003000 - Statement - Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 1002000 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 1004000 - Statement - Consolidated Statements of Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 2106100 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 2406403 - Disclosure - Debt - 2015 Convertible Notes (Details) link:presentationLink link:calculationLink link:definitionLink 2406402 - Disclosure - Debt - 2017 Credit Facility (Details) link:presentationLink link:calculationLink link:definitionLink 2406404 - Disclosure - Debt - Summary of convertible notes (Details) link:presentationLink link:calculationLink link:definitionLink 2406405 - Disclosure - Debt - Summary of Interest Expense (Details) link:presentationLink link:calculationLink link:definitionLink 2306301 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 0001000 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 2108100 - Disclosure - Earnings per share link:presentationLink link:calculationLink link:definitionLink 2408402 - Disclosure - Earnings per share (Details) link:presentationLink link:calculationLink link:definitionLink 2308301 - Disclosure - Earnings per share (Tables) link:presentationLink link:calculationLink link:definitionLink 2102100 - Disclosure - Fair value of financial instruments and investments link:presentationLink link:calculationLink link:definitionLink 2402405 - Disclosure - Fair value of financial instruments and investments - Available-for-sale securities (Details) link:presentationLink link:calculationLink link:definitionLink 2402408 - Disclosure - Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) link:presentationLink link:calculationLink link:definitionLink 2402406 - Disclosure - Fair value of financial instruments and investments - Marketable Securities, Balance Sheet Disclosures (Details) link:presentationLink link:calculationLink link:definitionLink 2402404 - Disclosure - Fair value of financial instruments and investments - Marketable Securities, Unrealized Gains (Losses) (Details) link:presentationLink link:calculationLink link:definitionLink 2402402 - Disclosure - Fair value of financial instruments and investments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2402403 - Disclosure - Fair value of financial instruments and investments - Schedule of financial assets and liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 2402407 - Disclosure - Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) link:presentationLink link:calculationLink link:definitionLink 2302301 - Disclosure - Fair value of financial instruments and investments (Tables) link:presentationLink link:calculationLink link:definitionLink 2104100 - Disclosure - Fixed assets link:presentationLink link:calculationLink link:definitionLink 2404402 - Disclosure - Fixed assets (Details) link:presentationLink link:calculationLink link:definitionLink 2304301 - Disclosure - Fixed assets (Tables) link:presentationLink link:calculationLink link:definitionLink 2116100 - Disclosure - Geographic information link:presentationLink link:calculationLink link:definitionLink 2416402 - Disclosure - Geographic information (Details) link:presentationLink link:calculationLink link:definitionLink 2316301 - Disclosure - Geographic information (Tables) link:presentationLink link:calculationLink link:definitionLink 2114100 - Disclosure - Income taxes link:presentationLink link:calculationLink link:definitionLink 2414406 - Disclosure - Income taxes - Deferred Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 2414403 - Disclosure - Income taxes - Loss from operations before tax (Details) link:presentationLink link:calculationLink link:definitionLink 2414402 - Disclosure - Income taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2414404 - Disclosure - Income taxes - Provision for Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 2314301 - Disclosure - Income taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 2414405 - Disclosure - Income taxes - Tax Rate Reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 2119100 - Disclosure - Intangible assets and goodwill link:presentationLink link:calculationLink link:definitionLink 2419403 - Disclosure - Intangible assets and goodwill - Future Amortization (Details) link:presentationLink link:calculationLink link:definitionLink 2419402 - Disclosure - Intangible assets and goodwill - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2319301 - Disclosure - Intangible assets and goodwill (Tables) link:presentationLink link:calculationLink link:definitionLink 2110100 - Disclosure - Other comprehensive income (loss) and accumulated other comprehensive items link:presentationLink link:calculationLink link:definitionLink 2410402 - Disclosure - Other comprehensive income (loss) and accumulated other comprehensive items (Details) link:presentationLink link:calculationLink link:definitionLink 2310301 - Disclosure - Other comprehensive income (loss) and accumulated other comprehensive items (Tables) link:presentationLink link:calculationLink link:definitionLink 2118100 - Disclosure - Restructuring link:presentationLink link:calculationLink link:definitionLink 2418401 - Disclosure - Restructuring - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2112100 - Disclosure - Revenue recognition link:presentationLink link:calculationLink link:definitionLink 2412405 - Disclosure - Revenue recognition - Balance Sheet Impacts (Details) link:presentationLink link:calculationLink link:definitionLink 2412408 - Disclosure - Revenue recognition - Cash Flow Impacts (Details) link:presentationLink link:calculationLink link:definitionLink 2412407 - Disclosure - Revenue recognition - Comprehensive Income Impacts (Details) link:presentationLink link:calculationLink link:definitionLink 2412403 - Disclosure - Revenue recognition - Contract Liabilities, Rollforward (Details) link:presentationLink link:calculationLink link:definitionLink 2412406 - Disclosure - Revenue recognition - Income Statement Impacts (Details) link:presentationLink link:calculationLink link:definitionLink 2412402 - Disclosure - Revenue recognition - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2412409 - Disclosure - Revenue recognition Recenue recognition - Roche and SMA Foundation (Details) link:presentationLink link:calculationLink link:definitionLink 2412404 - Disclosure - Revenue recognition - Recognized revenue in the period (Details) link:presentationLink link:calculationLink link:definitionLink 2312301 - Disclosure - Revenue recognition (Tables) link:presentationLink link:calculationLink link:definitionLink 2421402 - Disclosure - Selected quarterly financial data (Details) link:presentationLink link:calculationLink link:definitionLink 2321301 - Disclosure - Selected quarterly financial data (Tables) link:presentationLink link:calculationLink link:definitionLink 2121100 - Disclosure - Selected quarterly financial data (Unaudited) link:presentationLink link:calculationLink link:definitionLink 2109100 - Disclosure - Stock award plan link:presentationLink link:calculationLink link:definitionLink 2409404 - Disclosure - Stock award plan - Assumptions Used (Details) link:presentationLink link:calculationLink link:definitionLink 2409402 - Disclosure - Stock award plan - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2409405 - Disclosure - Stock award plan - Restricted Stock Activity (Details) link:presentationLink link:calculationLink link:definitionLink 2409406 - Disclosure - Stock award plan - Share-based Compensation (Details) link:presentationLink link:calculationLink link:definitionLink 2409403 - Disclosure - Stock award plan - Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 2309301 - Disclosure - Stock award plan (Tables) link:presentationLink link:calculationLink link:definitionLink 2120100 - Disclosure - Subsequent events link:presentationLink link:calculationLink link:definitionLink 2420401 - Disclosure - Subsequent events - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2101100 - Disclosure - Summary of significant accounting policies link:presentationLink link:calculationLink link:definitionLink 2401403 - Disclosure - Summary of significant accounting policies - Fixed Assets (Details) link:presentationLink link:calculationLink link:definitionLink 2401405 - Disclosure - Summary of significant accounting policies - Inventory (Details) link:presentationLink link:calculationLink link:definitionLink 2401404 - Disclosure - Summary of significant accounting policies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2201201 - Disclosure - Summary of significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 2301302 - Disclosure - Summary of significant accounting policies (Tables) link:presentationLink link:calculationLink link:definitionLink