Statement of Financial Position [Abstract] Assets Assets [Abstract] Current assets: Assets, Current [Abstract] Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Marketable securities Marketable Securities, Current Trade receivables, net Receivables, Net, Current Inventory Inventory, Net Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Total current assets Assets, Current Fixed assets, net Property, Plant and Equipment, Net Intangible assets, net Intangible Assets, Net (Excluding Goodwill) Goodwill Goodwill Deposits and other assets Deposits and Other Assets Noncurrent Represents the carrying value of amounts transferred to third parties for security purposes and other noncurrent assets that are expected to be returned or applied towards payment after one year or beyond the operating cycle, if longer. Total assets Assets Liabilities and stockholders’ equity Liabilities and Equity [Abstract] Current liabilities: Liabilities, Current [Abstract] Accounts payable and accrued expenses Accounts Payable and Accrued Liabilities, Current Current portion of long-term debt Long-term Debt, Current Maturities Deferred revenue Contract with Customer, Liability, Current Other current liabilities Other Liabilities, Current Deferred consideration payable- current Business Combination, Consideration, Liability, Deferred Consideration Payable- Current Business Combination, Consideration, Liability, Deferred Consideration Payable- Current Total current liabilities Liabilities, Current Deferred revenue - long-term Contract with Customer, Liability, Noncurrent Long-term debt Long-term Debt, Excluding Current Maturities Contingent consideration payable Business Combination, Contingent Consideration, Liability, Noncurrent Deferred consideration payable- long-term Business Combination, Consideration, Liability, Deferred Consideration Payable, Long Term Business Combination, Consideration, Liability, Deferred Consideration Payable, Long Term Deferred tax liability Deferred Tax Liabilities, Net, Noncurrent Other long-term liabilities Other Liabilities, Noncurrent Total liabilities Liabilities Stockholders’ equity: Stockholders' Equity Attributable to Parent [Abstract] Common stock, $0.001 par value. Authorized 125,000,000 shares; issued and outstanding 50,606,147 shares at December 31, 2018. Authorized 125,000,000 shares; issued and outstanding 41,612,395 shares at December 31, 2017. Common Stock, Value, Issued Additional paid-in capital Additional Paid in Capital Accumulated other comprehensive income Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated deficit Retained Earnings (Accumulated Deficit) Total stockholders’ equity Stockholders' Equity Attributable to Parent Total liabilities and stockholders’ equity Liabilities and Equity Income Tax Disclosure [Abstract] Income taxes Income Tax Disclosure [Text Block] Commitments and Contingencies Disclosure [Abstract] Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract] Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract] 2019 Lessee, Operating Lease, Liability, Payments, Due Next Twelve Months 2020 Lessee, Operating Lease, Liability, Payments, Due Year Two 2021 Lessee, Operating Lease, Liability, Payments, Due Year Three 2022 Lessee, Operating Lease, Liability, Payments, Due Year Four 2023 and thereafter Lessee, Operating Lease, Liability, Payments, Due Year Five and Thereafter Lessee, Operating Lease, Liability, Payments, Due Year Five and Thereafter Total future minimum lease payments Lessee, Operating Lease, Liability, Payments, Due Statement [Table] Statement [Table] Product and Service [Axis] Product and Service [Axis] Product and Service [Domain] Product and Service [Domain] Early Stage Collaborations Early Stage Collaborations [Member] Early Stage Collaborations [Member] Milestone [Axis] Milestone [Axis] Information by categories of milestones achieved. Milestone [Domain] Milestone [Domain] Different categories of milestones defined by agreements. Research And Development Event Milestones Research And Development Event Milestones [Member] Represents information pertaining to certain research and development events on the basis of which certain milestones are achieved. Statement [Line Items] Statement [Line Items] Deferred tax assets: Deferred Tax Assets, Net of Valuation Allowance [Abstract] Accrued expense Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities Amortization Deferred Tax Assets Amortization Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from amortization. Depreciation Deferred Tax Assets, Property, Plant and Equipment Federal tax credits Deferred Tax Assets Tax Credit Federal Represents the amount before allocation of valuation allowances of deferred tax asset attributable to deductible federal tax credit. State tax credits Deferred Tax Assets Tax Credit State Represents the amount before allocation of valuation allowances of deferred tax asset attributable to deductible state tax credit. Federal net operating losses Deferred Tax Assets, Operating Loss Carryforwards, Domestic State net operating losses Deferred Tax Assets, Operating Loss Carryforwards, State and Local Foreign net operating losses Deferred Tax Assets, Operating Loss Carryforwards, Foreign Capitalized research and development costs Deferred Tax Assets Deferred Expense Capitalized Research and Development Costs Amount before allocation of valuation allowances of deferred tax asset attributable to taxable temporary differences from capitalized research and development costs. Share based compensation and other Deferred Tax Assets, Other Total gross deferred tax assets Deferred Tax Assets, Gross Less valuation allowance Deferred Tax Assets, Valuation Allowance Deferred Tax Assets, Net of Valuation Allowance Deferred Tax Assets, Net of Valuation Allowance Deferred tax liabilities: Deferred Tax Liabilities, Net [Abstract] Convertible debt Deferred Tax Liabilities Convertible Debt Amount of deferred tax consequences attributable to convertible debt. OCI unrealized (gains)/losses Deferred Tax Liabilities, Unrealized Gains on Trading Securities Indefinite lived intangible Deferred Tax Liabilities, Intangible Assets Total gross deferred tax liabilities Deferred Tax Liabilities, Gross Deferred Tax Liabilities, Net Deferred Tax Liabilities, Net Revenue Recognition, Milestone, Potential Achievements Revenue Recognition, Milestone, Potential Achievements Revenue Recognition, Milestone, Potential Achievements Property, Plant and Equipment [Abstract] Schedule of fixed assets, net Property, Plant and Equipment [Table Text Block] Commitments and contingencies Commitments and Contingencies Disclosure [Text Block] Business Combinations [Abstract] Schedule of Business Acquisitions Schedule of Business Acquisitions, by Acquisition [Table Text Block] Preliminary Allocation and Purchase Consideration Schedule of Recognized Identified Assets Acquired and Liabilities Assumed [Table Text Block] Business Acquisition, Pro Forma Information Business Acquisition, Pro Forma Information [Table Text Block] Schedule of Purchase Price Schedule Of Purchase Price [Table Text Block] Schedule Of Purchase Price [Table Text Block] Schedule of Income before Income Tax, Domestic and Foreign Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] Components of Income Tax Provision Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] Schedule of reconciliation of the U.S. statutory income tax rate to the Company's effective tax rate Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] Schedule of significant components of the Company's deferred tax assets and liabilities Schedule of Deferred Tax Assets and Liabilities [Table Text Block] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] Income Statement Location [Axis] Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Research and development Research and Development Expense [Member] Selling, general and administrative Selling, General and Administrative Expenses [Member] Share-based compensation expense recorded in the statement of operations Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] Share-based compensation expense Allocated Share-based Compensation Expense Debt Disclosure [Abstract] Schedule of Long-term Debt Instruments [Table] Schedule of Long-term Debt Instruments [Table] Long-term Debt, Type [Axis] Long-term Debt, Type [Axis] Long-term Debt, Type [Domain] Long-term Debt, Type [Domain] Convertible debt Convertible Debt [Member] Debt Instrument [Axis] Debt Instrument [Axis] Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] 3.00% Convertible senior notes due 2022 Convertible Senior Notes3.0 Percent Due2022 [Member] Represents the information pertaining to 3.00% convertible senior notes due 2022. Long-term debt Debt Instrument [Line Items] Principal Debt Instrument, Face Amount Less: Debt issuance costs Unamortized Debt Issuance Expense Less: Debt discount, net Debt Instrument, Unamortized Discount Net carrying amount Long-term Debt Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Plan Name [Axis] Plan Name [Axis] Plan Name [Domain] Plan Name [Domain] 2013 Stock Incentive Plan Stock Incentive Plan2013 [Member] Represents information pertaining to the 2013 Stock Incentive Plan. 2009 Equity and Long Term Incentive Plan Equity And Long Term Incentive Plan2009 [Member] Represents information pertaining to the 2009 Equity and Long-Term Incentive Plan. 2009 Equity and Long Term Incentive Plan and 2013 Stock Incentive Plan Equity2009 And Long Term Incentive Plan And Stock Incentive Plan2013 [Member] Represents information pertaining to the 2009 Equity and Long Term Incentive Plan and 2013 Stock Incentive Plan. 2013 Long Term Incentive Plan Long Term Incentive Plan2013 [Member] Represents information pertaining to the 2013 Long Term Incentive Plan. Inducement grant plan Inducement Grant Plan [Member] Represents information pertaining to inducement grant available to new employees. Employee Stock Ownership Plan (ESOP) Name [Axis] Employee Stock Ownership Plan (ESOP) Name [Axis] Employee Stock Ownership Plan (ESOP), Plan [Domain] Employee Stock Ownership Plan (ESOP), Plan [Domain] Employee Stock Purchase Plan Employee Stock [Member] Award Type [Axis] Award Type [Axis] Equity Award [Domain] Equity Award [Domain] Unvested restricted stock Restricted Stock [Member] Stock option Equity Option [Member] Stock Appreciation Rights (SARs) Stock Appreciation Rights (SARs) [Member] Class of Stock [Axis] Class of Stock [Axis] Class of Stock [Domain] Class of Stock [Domain] Common stock Common Stock [Member] Range [Axis] Range [Axis] Range [Domain] Range [Domain] Minimum Minimum [Member] Maximum Maximum [Member] Stock option plan Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Number of shares authorized (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized Options granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Number of shares available for issuance (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Number of additional shares authorized (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized Number of shares subject to outstanding awards (in shares) Share based Compensation Arrangement by Share based Payment Award Number of Shares Authorized Shares Subject to Outstanding Awards Represents the number of shares subject to outstanding awards used to calculate authorized shares. Annual increase in the number of shares on the first day of the fiscal year (in shares) Share based Compensation Arrangement by Share based Payment Award Number of Shares Authorized Annual Increase Number Represents the number of shares to be added annually on the first day of each fiscal year in the number of shares authorized. Annual increase in the number of shares outstanding on the first day of the fiscal year Share based Compensation Arrangement by Share based Payment Award Number of Shares Authorized Annual Increase as Percentage of Stock Outstanding Represents the percentage of shares outstanding to be added annually on the first day of each fiscal year in the number of shares authorized. Stock options granted, exercise price as percentage of the fair market value of common stock at grant date Share Based Compensation Arrangement by Share Based Payment Award Options Granted Exercise Price as Percentage of Fair Market Value of Common Stock Represents the exercise price expressed as a percentage of the fair market value of the common stock as of the date of grant, at which grantees can acquire the shares reserved for issuance of stock options awarded. Stock options granted to stockholder with specified ownership percentage, exercise price as percentage of the fair market value of common stock at grant date Share Based Compensation Arrangement by Share Based Payment Award Options Granted to Stockholders with Specified Ownership Percentage Exercise Price as Percentage of Fair Market Value of Common Stock Represents the exercise price expressed as a percentage of the fair market value of the common stock as of the date of grant, at which grantees with specified common stock ownership percentage can acquire the shares reserved for issuance of stock options awarded. Stockholder's specified ownership percentage Share Based Compensation Arrangement by Share Based Payment Award Stockholders Specified Ownership Percentage Represents the stockholder's specified ownership percentage of the entity's common stock used in determination of the exercise price of stock options granted. Expiration period Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period Vesting period Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period Granted (in dollars per share) Share Based Compensation Arrangement by Share Based Payment Award Options Grants in Period Exercise Price Represents the exercise price at which grantees can acquire the shares reserved for issuance of stock options awarded. Forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Expected dividend yield Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate Weighted average grant date fair value (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Award requisite service period Share-based Compensation Arrangement by Share-based Payment Award, Award Requisite Service Period Purchase price of common stock Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent Employee stock purchase plan, voting percentage limit Employee Stock Purchase Plan, Voting Percentage Limit, Percent Employee Stock Purchase Plan, Voting Percentage Limit, Percent Unrecognized compensation cost Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized Weighted average remaining service period for recognition of unrecognized compensation cost Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition Summary of stock option activity Share-based Compensation, Stock Options, Activity [Table Text Block] Schedule of assumptions used to estimate fair values of grants made on the date of grant Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Summary of information on the Company's restricted stock Nonvested Restricted Stock Shares Activity [Table Text Block] Schedule of share-based compensation expense recorded in the statement of operations Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] Stockholders' Equity Note [Abstract] Capital structure Stockholders' Equity Note Disclosure [Text Block] Fair Value Disclosures [Abstract] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Domain] Fair Value Hierarchy and NAV [Domain] Significant unobservable inputs (level 3) Fair Value, Inputs, Level 3 [Member] Business Acquisition [Axis] Business Acquisition [Axis] Business Acquisition, Acquiree [Domain] Business Acquisition, Acquiree [Domain] Agilis Agilis [Member] Agilis [Member] Liability Class [Axis] Liability Class [Axis] Fair Value by Liability Class [Domain] Fair Value by Liability Class [Domain] Warrants Warrant [Member] Commitments [Member] Commitments [Member] Fair value of warrant liability Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] Changes in the fair value of warrant liability Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Beginning balance Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value Change in fair value Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings Payments Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Purchases, (Sales), Issuances, (Settlements) Additions Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Issuances Ending balance Schedule of financial assets and liabilities that are required to be measured at fair value on a recurring basis Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Summary of marketable securities accounted for as available-for-sale securities Schedule of Available-for-sale Securities Reconciliation [Table Text Block] Available-for-sale securities, continuous unrealized loss position, fair value Debt Securities, Available-for-sale, Unrealized Loss Position, Fair Value [Table Text Block] Schedule of marketable securities on the balance sheet Marketable Securities [Table Text Block] Fair value of the Company's Level 3 valuation for warrant liability Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block] Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Type [Domain] Leasehold improvements Leasehold Improvements [Member] Computer equipment and software Computer Equipment And Software [Member] Represents information pertaining to computer equipment, purchased software applications and internally developed software for sale, licensing or long-term internal use. Furniture, fixtures, and lab equipment Furniture Fixtures And Lab Equipment [Member] Represents information pertaining to furniture, fixture and lab equipment of the entity. Assets in process Asset under Construction [Member] Fixed assets Property, Plant and Equipment [Line Items] Gross fixed assets Property, Plant and Equipment, Gross Less accumulated depreciation and amortization Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Net fixed assets Depreciation Depreciation Accounting Policies [Abstract] Inventory Write-down Inventory Write-down Raw materials Inventory, Raw Materials, Gross Work in progress Inventory, Work in Process, Gross Finished goods Inventory, Finished Goods, Gross Total inventory Current: Current Income Tax Expense (Benefit), Continuing Operations [Abstract] U.S. Federal Current Federal Tax Expense (Benefit) U.S. State and Local Current State and Local Tax Expense (Benefit) Foreign Current Foreign Tax Expense (Benefit) Deferred: Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract] U.S. Federal Deferred Federal Income Tax Expense (Benefit) U.S. State and Local Deferred State and Local Income Tax Expense (Benefit) Foreign Deferred Foreign Income Tax Expense (Benefit) Total tax benefit (expense) Income Tax Expense (Benefit) Goodwill and Intangible Assets Disclosure [Abstract] Future amortization expense Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block] Fair Value Measurements, Recurring and Nonrecurring [Table] Fair Value Measurements, Recurring and Nonrecurring [Table] Measurement Basis [Axis] Measurement Basis [Axis] Fair Value Measurement [Domain] Fair Value Measurement [Domain] Portion at Fair Value Measurement Portion at Fair Value Measurement [Member] Total Estimate of Fair Value Measurement [Member] Type of Arrangement and Non-arrangement Transactions [Axis] Type of Arrangement and Non-arrangement Transactions [Axis] Arrangements and Non-arrangement Transactions [Domain] Arrangements and Non-arrangement Transactions [Domain] Non-collaborative Arrangement Transactions Non-collaborative Arrangement Transactions [Member] Measurement Frequency [Axis] Measurement Frequency [Axis] Fair Value, Measurement Frequency [Domain] Fair Value, Measurement Frequency [Domain] Fair Value, Measurements, Recurring Fair Value, Measurements, Recurring [Member] Fair Value, Inputs, Level 2 Fair Value, Inputs, Level 2 [Member] Measurement Input Type [Axis] Measurement Input Type [Axis] Measurement Input Type [Domain] Measurement Input Type [Domain] Volatility Measurement Input, Option Volatility [Member] Risk free interest rate Measurement Input, Risk Free Interest Rate [Member] Fair value of common stock Measurement Input, Share Price [Member] Expected life Measurement Input, Expected Term [Member] Financial assets and liabilities measured at fair value on recurring basis Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Marketable securities Debt Securities, Available-for-sale Interest rate Debt Instrument, Interest Rate, Stated Percentage Debt instrument Debt Instrument, Fair Value Disclosure Development milestone payment obligations Development Milestone Payment Obligations Represents the development milestones payments which the entity is obligated to pay under certain contractual agreements. Alternative Investment, Measurement Input Alternative Investment, Measurement Input Deferred consideration payable Business Combination, Consideration, Liability, Deferred Consideration Payable Business Combination, Consideration, Liability, Deferred Consideration Payable Priority review voucher amount Contingent Liability, Milestone, Potential Achievements, Priority Review Voucher Amount Contingent Liability, Milestone, Potential Achievements, Priority Review Voucher Amount Net sales milestones Contingent Liability, Milestone, Potential Achievements, Net Sales Milestone Contingent Liability, Milestone, Potential Achievements, Net Sales Milestone Percentage of annual net sales Contingent Liability, Milestone, Potential Achievements, Product Sales Percentage Contingent Liability, Milestone, Potential Achievements, Product Sales Percentage Warrant liability Warrants and Rights Outstanding Stock appreciation rights liability Stock Appreciation Rights Liability Outstanding Represents the amount of outstanding stock appreciation rights liability. Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value Statement of Comprehensive Income [Abstract] Net loss Net Income (Loss) Attributable to Parent Other comprehensive loss: Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Unrealized gain on marketable securities, net of tax Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Foreign currency translation (loss) gain Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Income Statement [Abstract] Net product revenue Product [Member] Collaboration and grant revenue Grant And Collaboration [Member] Grant And Collaboration [Member] Operating expenses: Operating Expenses [Abstract] Cost of product sales, excluding amortization of acquired intangible asset Cost of Goods Sold, Excluding Depreciation, Depletion, and Amortization Amortization of acquired intangible asset Amortization of Intangible Assets Research and development Research and Development Expense Selling, general and administrative Selling, General and Administrative Expense Change in the fair value of deferred and contingent consideration Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Asset Total operating expenses Operating Expenses Loss from operations Operating Income (Loss) Interest expense, net Interest Income (Expense), Nonoperating, Net Other income (expense), net Other Nonoperating Income (Expense) Loss before income tax expense Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Income tax benefit (expense) Net loss attributable to common stockholders Weighted-average shares outstanding: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Basic and diluted (in shares) Weighted Average Number of Shares Outstanding, Basic and Diluted Net loss per share—basic and diluted (in dollars per share) Earnings Per Share, Basic and Diluted Net product revenue Revenue from Contract with Customer, Including Assessed Tax Operating Loss Carryforwards [Table] Operating Loss Carryforwards [Table] Adjustments for New Accounting Pronouncements [Axis] Adjustments for New Accounting Pronouncements [Axis] Type of Adoption [Domain] Type of Adoption [Domain] Income Tax Authority [Axis] Income Tax Authority [Axis] Income Tax Authority [Domain] Income Tax Authority [Domain] Federal Domestic Tax Authority [Member] State State and Local Jurisdiction [Member] Foreign Tax Authority Foreign Tax Authority [Member] Tax Period [Axis] Tax Period [Axis] Tax Period [Domain] Tax Period [Domain] First five years from ownership change First Five Years [Member] Represents the use of carryforwards for first five years. After five years There After Five Years [Member] Represents the use of carryforwards for after five years. Operating loss carryforwards Operating Loss Carryforwards [Line Items] Valuation allowance Valuation allowance, deferred tax asset, increase (decrease) Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount Net operating loss carryforwards Operating Loss Carryforwards Deferred Tax Assets, Operating Loss Carryforwards, Limited by IRC Section 382 Deferred Tax Assets, Operating Loss Carryforwards, Limited by IRC Section 382 Deferred Tax Assets, Operating Loss Carryforwards, Limited by IRC Section 382 Research and development credit carryforwards Tax Credit Carryforward, Amount Orphan drug credit carryover Deferred Tax Assets, Tax Credit Carryforwards, General Business Limited NOL carryforwards Deferred Tax Assets, Operating Loss Carryforwards Operating loss carryforwards, not subject to expiration Deferred Tax Assets, Operating Loss Carryforwards, Not Subject to Expiration Operating loss carryforwards, subject to expiration Deferred Tax Assets, Operating Loss Carryforwards, Subject to Expiration Operating loss carryforwards for immediate use Operating Loss Carryforwards for Immediate Use Represents the operating loss carryforwards for immediate use. Operating loss carryforwards in next twelve months Operating Loss Carryforwards in Next Twelve Months Represents the operating loss carryforwards in next twelve months. Federal income tax provision at statutory rate Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent Uncertain tax position Liability for Uncertainty in Income Taxes, Current Change In tax rate, deferred tax asset, provisional income tax expense Tax Cuts And Jobs Act Of 2017 Change In Tax Rate Income Tax Expense (Benefit) Tax Cuts And Jobs Act Of 2017 Change In Tax Rate Income Tax Expense (Benefit) Statement of Stockholders' Equity [Abstract] Equity Components [Axis] Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Additional paid-in capital Additional Paid-in Capital [Member] Accumulated other comprehensive (loss) income AOCI Attributable to Parent [Member] Accumulated deficit Retained Earnings [Member] Common stock, authorized shares (in shares) Common Stock, Shares Authorized Increase (Decrease) in Stockholders' Equity Increase (Decrease) in Stockholders' Equity [Roll Forward] Balance (in shares) Shares, Issued Balance at the beginning of the period Adjustment to accumulated deficit Cumulative Effect of New Accounting Principle in Period of Adoption Issuance of common stock related to acquisition (in shares) Stock Issued During Period, Shares, Acquisitions Issuance of common stock related to acquisition Stock Issued During Period, Value, Acquisitions Issuance of common stock related to equity offering (in shares) Stock Issued During Period, Shares, New Issues Issuance of common stock related to equity offering Stock Issued During Period, Value, New Issues Exercise of options (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Exercise of options Stock Issued During Period, Value, Stock Options Exercised Restricted stock vesting and issuance (in shares) Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Restricted stock vesting and issuance Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Issuance of common stock in connection with an employee stock purchase plan (in shares) Stock Issued During Period, Shares, Employee Stock Purchase Plans Issuance of common stock in connection with an employee stock purchase plan Stock Issued During Period, Value, Employee Stock Purchase Plan Share-based compensation expense Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Receivable from investor Adjustments to Additional Paid In Capital, Receivable from Investor Adjustments to Additional Paid In Capital, Receivable from Investor Comprehensive loss Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Balance (in shares) Balance at the end of the period Fixed assets Property, Plant and Equipment Disclosure [Text Block] Summary of the Company's outstanding warrants Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Funding agreement Collaborative Arrangement, Product [Member] Counterparty Name [Axis] Counterparty Name [Axis] Counterparty Name [Domain] Counterparty Name [Domain] Wellcome trust limited Wellcome Trust Limited [Member] Represents information pertaining to The Wellcome Trust Limited. Akcea Akcea [Member] Akcea [Member] Other contingencies Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Number of Operating Leases Number of Operating Leases Operating Leases Operating Lease, Expense Operating Lease, Expense Development And Regulatory Milestone Payment Obligations, Period Development And Regulatory Milestone Payment Obligations, Period Development And Regulatory Milestone Payment Obligations, Period Upfront licensing fee Upfront Licensing Fee Upfront Licensing Fee Milestone, Potential Achievements, Regulatory Approval Milestone, Potential Achievements, Regulatory Approval Milestone, Potential Achievements, Regulatory Approval Basis of presentation Basis of Accounting, Policy [Policy Text Block] Use of estimates Use of Estimates, Policy [Policy Text Block] Consolidation Consolidation, Policy [Policy Text Block] Segment and geographic information Segment Reporting, Policy [Policy Text Block] Cash equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Marketable securities Marketable Securities, Policy [Policy Text Block] Fixed assets Property, Plant and Equipment, Policy [Policy Text Block] Concentration of credit risk Concentration Risk, Credit Risk, Policy [Policy Text Block] Inventories and cost of product sales Inventories And Cost Of Product Sales [Policy Text Block] Disclosure of accounting policy for inventories and cost of revenue. Deferred rent Deferred Charges, Policy [Policy Text Block] Accumulated other comprehensive income (loss) Comprehensive Income, Policy [Policy Text Block] Revenue recognition Revenue Recognition, Policy [Policy Text Block] Allowance for doubtful accounts Receivables, Trade and Other Accounts Receivable, Allowance for Doubtful Accounts, Policy [Policy Text Block] Research and development costs Research and Development Expense, Policy [Policy Text Block] Fair value of financial instruments Fair Value of Financial Instruments, Policy [Policy Text Block] Warrant liability Warrant Liability [Policy Text Block] Disclosure of accounting policy for warrant liability. Share-based compensation Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block] Income taxes Income Tax, Policy [Policy Text Block] Foreign currency Foreign Currency Transactions and Translations Policy [Policy Text Block] Net (loss) income per share Earnings Per Share, Policy [Policy Text Block] Business combinations and asset acquisitions Business Combinations and Other Purchase of Business Transactions, Policy [Policy Text Block] Finite-lived intangible assets Intangible Assets, Finite-Lived, Policy [Policy Text Block] Impairment of long-lived assets Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] Goodwill and Intangible Assets Goodwill and Intangible Assets, Policy [Policy Text Block] Recent accounting pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Estimated useful life Property, Plant and Equipment, Useful Life Fair Value, by Balance Sheet Grouping [Table] Fair Value, by Balance Sheet Grouping [Table] Quoted prices in active markets for identical assets (level 1) Fair Value, Inputs, Level 1 [Member] Significant other observable inputs (level 2) Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] Goodwill and Intangible Assets Disclosure Goodwill and Intangible Assets Disclosure [Text Block] Schedule of estimated useful life of related assets Property Plant and Equipment Useful Life [Table Text Block] Tabular disclosure of the useful life of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and are not intended for resale. Schedule of inventory Schedule of Inventory, Current [Table Text Block] Revenue from Contract with Customer [Abstract] Amounts included in contract liabilities at the beginning of the period Contract With Customer, Liability, Amounts Recognized Beginning Of Measurement Period Contract With Customer, Liability, Amounts Recognized Beginning Of Measurement Period Performance obligations satisfied in previous period Contract with Customer, Performance Obligation Satisfied in Previous Period Revenue from Contract with Customer, Including Assessed Tax Performance obligations satisfied in current period Contract with Customer, Liability, Revenue Recognized Total product revenue Net Product Sales Represents the amount of revenue earned from product sales during the reporting period. Organization, Consolidation and Presentation of Financial Statements [Abstract] The Company Nature of Operations [Text Block] Schedule of Finite-Lived Intangible Assets [Table] Schedule of Finite-Lived Intangible Assets [Table] Marathon Pharmaceuticals, LLC Marathon Pharmaceuticals, LLC [Member] Marathon Pharmaceuticals, LLC [Member] Finite-Lived Intangible Assets by Major Class [Axis] Finite-Lived Intangible Assets by Major Class [Axis] Finite-Lived Intangible Assets, Major Class Name [Domain] Finite-Lived Intangible Assets, Major Class Name [Domain] Intellectual Property Intellectual Property [Member] Finite-Lived Intangible Assets [Line Items] Finite-Lived Intangible Assets [Line Items] 2019 Finite-Lived Intangible Assets, Amortization Expense, Next Twelve Months 2020 Finite-Lived Intangible Assets, Amortization Expense, Year Two 2021 Finite-Lived Intangible Assets, Amortization Expense, Year Three 2022 Finite-Lived Intangible Assets, Amortization Expense, Year Four 2023 and thereafter Finite-Lived Intangible Assets, Amortization Expense Year Five And Thereafter Finite-Lived Intangible Assets, Amortization Expense Year Five And Thereafter Total Finite-Lived Intangible Assets, Net Quarterly Financial Information Disclosure [Abstract] Collaboration and grant revenue Collaboration and grant revenue Amount of revenue earned from collaborative research and development and licensing agreements and non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements. Operating expenses Revenue, Initial Application Period Cumulative Effect Transition [Table] Revenue, Initial Application Period Cumulative Effect Transition [Table] Initial Application Period Cumulative Effect Transition [Axis] Initial Application Period Cumulative Effect Transition [Axis] Initial Application Period Cumulative Effect Transition [Domain] Initial Application Period Cumulative Effect Transition [Domain] Adjustments Difference between Revenue Guidance in Effect before and after Topic 606 [Member] Balances without adoption of Topic 606 Calculated under Revenue Guidance in Effect before Topic 606 [Member] ASU 2014-09 Accounting Standards Update 2014-09 [Member] Revenue, Initial Application Period Cumulative Effect Transition [Line Items] Revenue, Initial Application Period Cumulative Effect Transition [Line Items] Unrealized gain (loss) on marketable securities Fair value of financial instruments and investments Fair Value Disclosures [Text Block] Credit Facility [Axis] Credit Facility [Axis] Credit Facility [Domain] Credit Facility [Domain] MidCap Financial Trust MidCap Financial Trust [Member] MidCap Financial Trust [Member] Variable Rate [Axis] Variable Rate [Axis] Variable Rate [Domain] Variable Rate [Domain] LIBOR London Interbank Offered Rate (LIBOR) [Member] Line of credit facility, maximum borrowing capacity Line of Credit Facility, Maximum Borrowing Capacity Proceeds from lines of credit Proceeds from Lines of Credit Additional capacity available Line Of Credit Facility, Additional Capacity Available Line Of Credit Facility, Additional Capacity Available Debt issuance costs, line of credit arrangements Debt Issuance Costs, Line of Credit Arrangements, Gross Floor interest rate Debt Instrument, Floor Interest Rate Debt Instrument, Floor Interest Rate Basis spread on variable rate Debt Instrument, Basis Spread on Variable Rate Interest payment period Debt Instrument, Interest Payment Period Debt Instrument, Interest Payment Period Selected quarterly financial data (Unaudited) Quarterly Financial Information [Text Block] Debt Debt and Capital Leases Disclosures [Text Block] Summary of convertible notes Convertible Debt [Table Text Block] Summary of interest expense recognized related to the Convertible Notes Schedule Of Interest Expense Recognized Related To Convertible Debt [Table Text Block] Tabular disclosure of interest expense recognized related to convertible debt. Valuation assumptions Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract] Risk-free interest rate Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Expected volatility Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate Expected term Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Acquisitions Asset Acquisition [Text Block] Asset Acquisition [Text Block] Segments, Geographical Areas [Abstract] Summary of financial information based on geographical location Schedule of Revenue from External Customers and Long-Lived Assets, by Geographical Areas [Table Text Block] Restructuring and Related Activities [Abstract] Restructuring Restructuring and Related Activities Disclosure [Text Block] Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] Summary of other comprehensive income (loss) and the changes in accumulated other comprehensive items Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block] Debt Instrument, Redemption, Period [Axis] Debt Instrument, Redemption, Period [Axis] Debt Instrument, Redemption, Period [Domain] Debt Instrument, Redemption, Period [Domain] Redemption on or after August 20, 2018 Debt Instrument Conversion Period On Or After August202018 [Member] Represents the debt instrument redemption period on or after August 20, 2018. Debt instrument Net proceeds from issuance of convertible notes Proceeds from Debt, Net of Issuance Costs Trading days, number Debt Instrument, Convertible, Threshold Trading Days Consecutive trading days, period Debt Instrument, Convertible, Threshold Consecutive Trading Days Stock price trigger Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger Business days, period Debt Instrument Convertible Threshold Business Days Threshold period of specified business days within which the maximum product of the closing sale price of shares of the entity's common stock and the applicable conversion rate for such trading day triggers the conversion feature. Consecutive trading-day period Debt Instrument Convertible Threshold Consecutive Trading Day Period Threshold period of specified consecutive trading days within which the maximum product of the closing sale price of shares of the entity's common stock and the applicable conversion rate for such trading day triggers the conversion feature. Maximum product of the closing sale price of shares of the Company's common stock and the applicable conversion rate for such trading day Debt Instrument Convertible Threshold Sale Price Of Common Stock Conversion Rate Product Percentage Maximum Represents the maximum product of the closing sale price of shares of the entity's common stock and the applicable conversion rate for such trading day. Conversion ratio Debt Instrument, Convertible, Conversion Ratio Conversion price per share Debt Instrument, Convertible, Conversion Price Redemption price Debt Instrument, Redemption Price, Percentage Minimum percentage of principal held by convertible debt instrument holders required to issue notice for declaration of principal and unpaid interest payable upon events of default Minimum Percentage Of Debt Principal Amount By Instrument Holders Represents the minimum percentage of debt principal amount by instrument holders. Convertible instruments principal and unpaid interest payable upon events of default Convertible Instruments Principal And Unpaid Interest Payable Upon Events Of Default Represents the debt instrument principal and unpaid interest payable upon events of default. Term of the convertible notes Debt Instrument, Term Net deferred tax liability in connection with convertible notes Net Deferred Tax Liabilities Convertible Debt Instruments Amount of net deferred tax liability attributable to taxable temporary differences from issuance of convertible debt instruments. Remaining amortization period Debt Instrument, Convertible, Remaining Discount Amortization Period Translarna Translarna [Member] Translarna [Member] Minimum age of ambulatory patient Minimum age of Ambulatory Patient Represents the minimum age of ambulatory patient. Number of countries (over) Number of Countries in which Entity Operates Accumulated deficit Cash consideration Payments to Acquire Businesses, Gross Equity interest issued or issuable, number of shares (in shares) Business Acquisition, Equity Interest Issued or Issuable, Number of Shares Numerator for calculation of number of shares of equity interests issued to acquire entity Business Acquisition, Numerator For Calculation Of Number Of Shares Of Equity Interests Issued To Acquire Entity Business Acquisition, Numerator For Calculation Of Number Of Shares Of Equity Interests Issued To Acquire Entity Trading day period Business Acquisition, Equity Interest Issued Or Issuable, Trading Day Period Business Acquisition, Equity Interest Issued Or Issuable, Trading Day Period Emflaza Emflaza [Member] Emflaza [Member] Emflaza asset acquisition Emflaza asset acquisition [Member] Emflaza asset acquisition [Member] Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles Useful life Finite-Lived Intangible Asset, Useful Life Finite-Lived Intangible Assets, Accumulated Amortization Finite-Lived Intangible Assets, Accumulated Amortization Total allocation of IPR&D assets Indefinite-lived Intangible Assets Acquired Goodwill Adjustment Goodwill, Purchase Accounting Adjustments Schedule of Business Acquisitions, by Acquisition [Table] Schedule of Business Acquisitions, by Acquisition [Table] Contingent Consideration by Type [Axis] Contingent Consideration by Type [Axis] Contingent Consideration Type [Domain] Contingent Consideration Type [Domain] Liability, Development and Regulatory Milestone Liability, Development and Regulatory Milestone [Member] Liability, Development and Regulatory Milestone [Member] Liability, Net Sales Milestones and Royalties Liability, Net Sales Milestones and Royalties [Member] Liability, Net Sales Milestones and Royalties [Member] Business Acquisition [Line Items] Business Acquisition [Line Items] Change in fair value Number of Shares Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Balance at the beginning of the period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Granted (in shares) Vested (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period Balance at the end of the period (in shares) Weighted Average Grant Date Fair Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Balance at the beginning of the period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Granted (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Vested (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Forfeited (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Balance at the end of the period (in dollars per share) Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Common stock, issued shares (in shares) Common Stock, Shares, Issued Common stock, outstanding shares (in shares) Common Stock, Shares, Outstanding Cash flows from operating activities Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Depreciation and amortization Depreciation, Depletion and Amortization Change in the fair value of deferred and contingent consideration Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability Amortization of premiums and accretion of discounts on investments, net Accretion (Amortization) of Discounts and Premiums, Investments Non-cash interest expense Paid-in-Kind Interest Loss on disposal of asset Gain (Loss) on Disposition of Assets Amortization of debt issuance costs Amortization of Debt Issuance Costs Share-based compensation expense Share-based Compensation Unrealized foreign currency transaction gains Foreign Currency Transaction Gain (Loss), Unrealized Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Inventory Increase (Decrease) in Inventories Prepaid expenses and other current assets Increase (Decrease) in Prepaid Expense and Other Assets Trade receivables, net Increase (Decrease) in Receivables Deposits and other assets Increase (Decrease) in Deposit Assets Accounts payable and accrued expenses Increase (Decrease) in Accounts Payable and Accrued Liabilities Other liabilities Increase (Decrease) in Other Operating Liabilities Deferred revenue Increase (Decrease) in Contract with Customer, Liability Net cash used in operating activities Net Cash Provided by (Used in) Operating Activities Cash flows from investing activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Purchases of fixed assets Payments to Acquire Property, Plant, and Equipment Purchases of marketable securities Payments to Acquire Marketable Securities Sale & redemption of marketable securities Proceeds from Sale and Maturity of Marketable Securities Acquisition of product rights Payments to Acquire Intangible Assets Business acquisition, net of cash acquired Payments to Acquire Businesses, Net of Cash Acquired Net cash (used in) provided by investing activities Net Cash Provided by (Used in) Investing Activities Cash flows from financing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Proceeds from exercise of options Proceeds from Stock Options Exercised Net proceeds from public offerings Proceeds from Issuance of Common Stock Proceeds from shares issued under employee stock purchase plan Proceeds from Stock Plans Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Effect of exchange rate changes on cash Effect of Exchange Rate on Cash and Cash Equivalents Net increase in cash and cash equivalents Cash and Cash Equivalents, Period Increase (Decrease) Cash and cash equivalents, beginning of period Cash and cash equivalents, end of period Document and Entity Information No definition available. Entity Registrant Name Entity Registrant Name Entity Central Index Key Entity Central Index Key Document Type Document Type Document Period End Date Document Period End Date Amendment Flag Amendment Flag Current Fiscal Year End Date Current Fiscal Year End Date Entity Well-Known Seasoned Issuer Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Voluntary Filers Entity Current Reporting Status Entity Current Reporting Status Entity Filer Category Entity Filer Category Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company Entity Shell Company Entity Shell Company Entity Public Float Entity Public Float Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Payables and Accruals [Abstract] Accounts payable and accrued expenses Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-sale [Table] Financial Instrument [Axis] Financial Instrument [Axis] Financial Instruments [Domain] Financial Instruments [Domain] Commercial paper Commercial Paper, Not Included with Cash and Cash Equivalents [Member] Corporate debt securities Corporate Debt Securities [Member] Marketable securities accounted for as available-for-sale securities Debt Securities, Available-for-sale [Line Items] Amortized Cost Debt Securities, Available-for-sale, Amortized Cost Gross Unrealized Gains Available-for-sale Securities, Accumulated Gross Unrealized Gain, before Tax Gross Unrealized Losses Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax Fair Value Class of Warrant or Right [Table] Class of Warrant or Right [Table] 2018 Debt Instrument, Redemption, Period Three [Member] 2019, period one Debt Instrument, Redemption, Period One [Member] 2019, period two Debt Instrument, Redemption, Period Five [Member] Warrants Class of Warrant or Right [Line Items] Warrant shares (in shares) Class of Warrant or Right, Outstanding Exercise price (in dollars per share) Class of Warrant or Right, Exercise Price of Warrants or Rights Number of operating segments Number of Operating Segments Schedule of Segment Reporting Information, by Segment [Table] Schedule of Segment Reporting Information, by Segment [Table] Geographical [Axis] Geographical [Axis] Geographical [Domain] Geographical [Domain] United States UNITED STATES Non-US Non-US [Member] Segment Reporting Information [Line Items] Segment Reporting Information [Line Items] Total assets Property and equipment, net Revenue Revenues Contingent consideration payable Business Combination, Contingent Consideration, Liability Purchase price Asset Acquisition, Consideration Transferred Asset Acquisition, Consideration Transferred Inventory Assets Acquired, Inventory Assets Acquired, Inventory Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles Subsequent Events [Abstract] Subsequent Event [Table] Subsequent Event [Table] Subsequent Event Type [Axis] Subsequent Event Type [Axis] Subsequent Event Type [Domain] Subsequent Event Type [Domain] Subsequent Event Subsequent Event [Member] Subsequent Event [Line Items] Subsequent Event [Line Items] Common stock, issued and sold (in shares) Sale of Stock, Number of Shares Issued in Transaction Sale price (in USD per share) Sale of Stock, Price Per Share Exercise of Underwriter (in shares) Sale of Stock, Exercise of Underwriter Option Sale of Stock, Exercise of Underwriter Option Net proceeds from sale of stock Sale of Stock, Consideration Received on Transaction Contractual interest expense Interest Expense, Debt, Excluding Amortization Amortization of debt discount Amortization of Debt Discount (Premium) Total Interest Expense, Debt Effective interest rate of the liability component Debt Instrument, Interest Rate, Effective Percentage Retirement Benefits [Abstract] 401(k) plan Compensation and Employee Benefit Plans, Other than Share-based Compensation [Text Block] Subsequent events Subsequent Events [Text Block] Revenue recognition Revenue from Contract with Customer [Text Block] Summary of significant accounting policies Basis of Presentation and Significant Accounting Policies [Text Block] Segment and geographic information Segment Reporting [Abstract] Number of Reporting Units Number of Reporting Units Allowance for doubtful accounts Allowance for Doubtful Accounts Receivable Deferred research and development advance payments Deferred Research and Development Costs Represents the carrying amount of deferred research and development costs. Impairment of long-lived assets Asset Impairment Charges Schedule of Stock by Class [Table] Schedule of Stock by Class [Table] Difference between Revenue Guidance in Effect before and after Topic 606 Balance Sheet Location [Axis] Balance Sheet Location [Axis] Balance Sheet Location [Domain] Balance Sheet Location [Domain] Summary Class of Stock [Line Items] Cumulative Effect Of New Accounting Principle In Period Of Adoption, Variable Consideration Cumulative Effect Of New Accounting Principle In Period Of Adoption, Variable Consideration Cumulative Effect Of New Accounting Principle In Period Of Adoption, Variable Consideration Renewal Of Marketing Authorization, Period Renewal Of Marketing Authorization, Period Renewal Of Marketing Authorization, Period Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Deferred Tax Liabilities Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Deferred Tax Liabilities Contract with Customer, Liability, Cumulative Catch-up Adjustment to Revenue, Change in Measure of Progress Contract with Customer, Liability, Cumulative Catch-up Adjustment to Revenue, Change in Measure of Progress Nonrecurring Adjustment [Axis] Nonrecurring Adjustment [Axis] Nonrecurring Adjustment [Domain] Nonrecurring Adjustment [Domain] Acquisition-related Costs Acquisition-related Costs [Member] Fair value of PTC common stock issued Business Combination, Consideration Transferred, Equity Interests Issued and Issuable Estimated fair value of contingent consideration payable Business combination, consideration Business Combination, Consideration Transferred Acquisition Related Costs Business Combination, Acquisition Related Costs Net loss attributable to common stockholders Business Acquisition, Pro Forma Net Income (Loss) Earnings (loss) of acquire since acquisition date Business Combination, Pro Forma Information, Earnings or Loss of Acquiree since Acquisition Date, Actual Acquisition costs Asset Purchase, Acquisition Related Costs Asset Purchase, Acquisition Related Costs Revenues Business Acquisition, Pro Forma Revenue Contract liabilities, rollforward and revenue recognition Contract with Customer, Asset and Liability [Table Text Block] Schedule of New Accounting Pronouncements and Changes in Accounting Principles Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block] Accrued Restructuring Expenses Restructuring Reserve, Current Restructuring charge Restructuring and Related Cost, Expected Cost Cash consideration Fair value of PTC common stock issued to Marathon (6,683,598 shares) Total preliminary consideration transferred Reconciliation of the U.S. statutory income tax rate to the entity's effective tax rate Effective Income Tax Rate Reconciliation, Percent [Abstract] State income tax provision, net of federal benefit Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent Permanent differences Effective Income Tax Rate Reconciliation Permanent Differences Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to permanent differences. Research and development Effective Income Tax Rate Reconciliation, Nondeductible Expense, Research and Development, Percent Change in valuation allowances Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent Change in deferred tax assets Effective Income Tax Rate Reconciliation Tax Cuts And Jobs Act Of 2017 Transition Tax On Accumulated Foreign Earnings Percent Effective Income Tax Rate Reconciliation Tax Cuts And Jobs Act Of 2017 Transition Tax On Accumulated Foreign Earnings Percent Foreign tax rate differential Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent Benefit allocated from other comprehensive income Effective Income Tax Rate Reconciliation,Other Reconciling Items, Percent Other Effective Income Tax Rate Reconciliation, Other Adjustments, Percent Effective income tax rate Effective Income Tax Rate Reconciliation, Percent Schedule of Available-for-sale Securities [Table] Schedule of Available-for-sale Securities [Table] Commercial Paper Debt Securities, Available-for-sale [Line Items] Unrealized losses Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss Fair Value Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, Less than 12 Months Unrealized losses Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss Fair Value Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, 12 Months or Longer Unrealized losses Debt Securities, Available-for-sale, Unrealized Loss Position, Accumulated Loss Fair Value Debt Securities, Available-for-sale, Unrealized Loss Position Employee compensation, benefits, and related accruals Employee-related Liabilities, Current Consulting and contracted research Accrued Consulting and Contracted Research Current Represents the carrying value as of the balance sheet date of obligations incurred through that date and payable for consulting and contracted research. Professional fees Accrued Professional Fees, Current Sales allowances and other related costs Sales Allowance And Other Related Costs Sales Allowance And Other Related Costs Royalties and rebates Sales Rebates And Royalties, Current Sales Rebates And Royalties, Current Accounts payable Accounts Payable, Current Other Other Accrued Liabilities, Current Accounts payable and accrued expenses Revenues: Revenues [Abstract] Cost of product sales, excluding amortization of acquired intangible asset Cost of Goods and Services Sold Selling, general and administrative Interest expense, net Inventory, net Deferred consideration payable- current Business Combination, Contingent Consideration, Liability, Current Estimated fair value of deferred consideration payable Common stock, $0.001 par value. Authorized 125,000,000 shares; issued and outstanding 41,809,398 shares at March 31, 2018. Authorized 125,000,000 shares; issued and outstanding 41,612,395 shares at December 31, 2017 Schedule of components of accounts payable and accrued expenses Schedule of Accounts Payable and Accrued Liabilities [Table Text Block] Schedule of future minimum lease payments Lessee, Operating Lease, Liability, Maturity [Table Text Block] Statement of Cash Flows [Abstract] Cash flows from operating activities Net Cash Provided by (Used in) Operating Activities [Abstract] Change in valuation of warrant liability Fair Value Adjustment of Warrants Amortization of (discounts) premiums on investments, net Disposal of asset Benefit for deferred income taxes Deferred Income Tax Expense (Benefit) Unrealized foreign currency transaction (gains) losses, net Inventory, net Other liabilities Increase (Decrease) in Other Noncurrent Liabilities Cash flows from investing activities Net Cash Provided by (Used in) Investing Activities [Abstract] Sale & redemption of marketable securities Business acquisition, net of cash acquired Cash flows from financing activities Net Cash Provided by (Used in) Financing Activities [Abstract] Debt issuance costs related to secured term loan Payments of Debt Issuance Costs Net proceeds from public offering Proceeds from issuance of secured term loan Proceeds from Issuance of Secured Debt Supplemental disclosure of cash information Supplemental Cash Flow Information [Abstract] Cash paid for interest Interest Paid, Including Capitalized Interest, Operating and Investing Activities Cash paid for income taxes Income Taxes Paid, Net Supplemental disclosures of non-cash information related to investing and financing activities Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Change in unrealized gain on marketable securities, net of tax Change in Unrealized Gain (Loss) on Marketable Securities Represents change in the unrealized gain (loss) on marketable securities in noncash investing and financing activities. Acquisition of product rights and licenses Noncash or Part Noncash Acquisition, Intangible Assets Acquired Accumulated Other Comprehensive Income (Loss) [Table] Accumulated Other Comprehensive Income (Loss) [Table] Unrealized (Losses)/Gains On Marketable Securities, net of tax Accumulated Net Investment Gain (Loss) Attributable to Parent [Member] Foreign Currency Translation Accumulated Foreign Currency Adjustment Attributable to Parent [Member] Total Accumulated Other Comprehensive Items Other comprehensive income (loss) and accumulated other comprehensive items Accumulated Other Comprehensive Income (Loss) [Line Items] AOCI Attributable to Parent, Net of Tax [Roll Forward] AOCI Attributable to Parent, Net of Tax [Roll Forward] Other comprehensive income (loss) before reclassifications Other Comprehensive Income (Loss), before Reclassifications, Net of Tax Amounts reclassified from other comprehensive items Reclassification from AOCI, Current Period, Net of Tax, Attributable to Parent Other comprehensive income (loss) Other Comprehensive Income (Loss), Net of Tax Cash and cash equivalents Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Cash and Equivalents Prepaid expenses and other current assets Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Prepaid Expense and Other Assets Fixed assets Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment Other assets Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Other Assets Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Other Assets Intangible assets - IPR&D Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Intangible Assets, Other than Goodwill Intangible assets - in process research and development (“IPRD”) Adjustment Business Combination, Provisional Information, Initial Accounting Incomplete, Adjustment, Intangibles Indefinite-lived Intangible Assets Acquired Accounts payable and accrued expenses Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accounts Payable And Accrued Expenses Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accounts Payable And Accrued Expenses Deferred tax liability Deferred tax liability adjustment Business Combination, Provisional Information, Initial Accounting Incomplete, Adjustment, Deferred Income Taxes Business Combination, Provisional Information, Initial Accounting Incomplete, Adjustment, Deferred Income Taxes Fair value of net assets acquired Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Net Fair value of net assets acquired adjustment Business Combination, Provisional Information, Initial Accounting Incomplete, Adjustment, Net Assets Business Combination, Provisional Information, Initial Accounting Incomplete, Adjustment, Net Assets Total purchase price Business Combination, Recognized Identifiable Assets Acquired, Goodwill, and Liabilities Assumed, Net Total purchase price adjustment Business Combination, Provisional Information, Initial Accounting Incomplete, Adjustment, Assets Business Combination, Provisional Information, Initial Accounting Incomplete, Adjustment, Net of assets plus liability Investment Holdings [Table] Investment Holdings [Table] Investment Type [Axis] Investment Type [Axis] Investments [Domain] Investments [Domain] Marketable securities on the balance sheet Investment Holdings [Line Items] Less Than 12 Months Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, within One Year, Fair Value More Than 12 Months Available For Sale Securities Debt Maturities Over One Year Fair Value Amount of available-for-sale debt securities at fair value maturing after the next fiscal year following the latest fiscal year. Temporary Equity, by Class of Stock [Table] Temporary Equity, by Class of Stock [Table] Sale of Stock [Axis] Sale of Stock [Axis] Sale of Stock [Domain] Sale of Stock [Domain] Over-Allotment Option Over-Allotment Option [Member] Capital structure Temporary Equity [Line Items] Share Price Share Price Common stock, authorized shares (in shares) Movement in Deferred Revenue [Roll Forward] Movement in Deferred Revenue [Roll Forward] Beginning balance Contract with Customer, Liability Additions Contract With Customer, Liability, Increase From Cash Receipts Contract with Customer, Liability, Increase from Cash Receipts Deductions Contract with Customer, Liability, Change in Timeframe, Performance Obligation Satisfied, Revenue Recognized ASC 606 Adjustment Ending balance Number of options Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Outstanding at the beginning of the period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Exercised (in shares) Forfeited (in shares) Outstanding at the end of the period (in shares) Vested or expected to vest at the end of the period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number Exercisable at the end of the period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number Weighted- average exercise price Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Outstanding at the beginning of the period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Granted (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Exercised (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Forfeited (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Outstanding at the end of the period (in dollars per share) Vested or expected to vest at the end of the period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price Exercisable at the end of the period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price Weighted- average remaining contractual term Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract] Outstanding at the end of the period Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Vested or expected to vest at the end of the period Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Remaining Contractual Term Exercisable at the end of the period Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Aggregate intrinsic value Share Based Compensation Arrangement by Share Based Payment Award Options Intrinsic Value [Roll Forward] Outstanding at the end of the period (in dollars) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Vested or expected to vest at the end of the period (in dollars) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value Exercisable at the end of the period (in dollars) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value Potential net sales milestones Sales Milestones [Member] Represents information pertaining to certain sales events on the basis of which certain milestones are achieved. Collaborative Arrangement [Member] Collaborative Arrangement [Member] Collaboration And Discovery Agreements [Member] Collaboration And Discovery Agreements [Member] Represents information pertaining to early stage collaboration and discovery agreements. Roche And Sma Foundation [Member] Roche And Sma Foundation [Member] Represents information pertaining to Roche and SMA Foundation Licensing And Collaboration Agreement Licensing And Collaboration Agreement [Member] Licensing And Collaboration Agreement [Member] Grant [Member] Grant [Member] Net Product Sales Collaborative Arrangements Number of Compounds in Preclinical Development Collaborative Arrangements Number of Compounds in Preclinical Development Represents the number of compounds included in preclinical development. Collaborative Arrangements Number of Significant Deliverables Collaborative Arrangements Number of Significant Deliverables Represents the number of significant deliverables under a contractual agreement. Collaborative Arrangements Research Period for Applying Discovery Technology Collaborative Arrangements Research Period for Applying Discovery Technology Represents the research period for applying discovery technology. Term of Grant Program Term of Grant Program Represents the term of the grant program. Earnings Per Share [Abstract] Schedule of computation of basic and diluted net loss per share for common stockholders Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Schedule of historical dilutive common share equivalents outstanding Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Probabilities of success Probability of Success [Member] Probability of Success [Member] Potential percentage of net sales for royalties Percentage of Sales for Royalties [Member] Percentage of Sales for Royalties [Member] Potential development and regulatory milestones Development and Regulatory Milestone [Member] Development and Regulatory Milestone [Member] Discount rates Measurement Input, Discount Rate [Member] Other Comprehensive Income Location [Axis] Other Comprehensive Income Location [Axis] Other Comprehensive Income Location [Domain] Other Comprehensive Income Location [Domain] Summary of quarterly data Quarterly Financial Information [Table Text Block] Geographic information Segment Reporting Disclosure [Text Block] Other comprehensive income (loss) and accumulated other comprehensive items Comprehensive Income (Loss) Note [Text Block] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Stock Options Employee Stock Option [Member] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Net loss per share: Earnings Per Share, Basic and Diluted, Other Disclosures [Abstract] Basic and diluted (in dollars per share) Net loss per share Earnings Per Share, Basic and Diluted [Abstract] Numerator Net Income (Loss) Available to Common Stockholders, Basic [Abstract] Denominator Denominator for basic and diluted net loss per share (in shares) Total shares excluded from calculation (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Earnings per share Earnings Per Share [Text Block] Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis] Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis] Revenue, Remaining Performance Obligation, Amount Revenue, Remaining Performance Obligation, Amount Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period Matching contribution (as a percent of total salary) Defined Contribution Plan, Employer Matching Contribution, Percent of Match Percentage of employee's base salary, matched by employer Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay Expense recorded Defined Contribution Plan, Cost Stock award plan Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Domestic Income (Loss) from Continuing Operations before Income Taxes, Domestic Foreign Income (Loss) from Continuing Operations before Income Taxes, Foreign Total Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Noncontrolling Interest