Cover [Abstract] Document Type Document Type Document Annual Report Document Period End Date Document Period End Date Document Transition Report Document Transition Report Entity File Number Entity File Number Entity Registrant Name Entity Registrant Name Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Tax Identification Number Entity Address, Address Line One Entity Address, Address Line One Entity Address, City or Town Entity Address, City or Town Entity Address, State or Province Entity Address, State or Province Entity Address, Postal Zip Code Entity Address, Postal Zip Code City Area Code City Area Code Local Phone Number Local Phone Number Title of 12(b) Security Title of 12(b) Security Trading Symbol Trading Symbol Security Exchange Name Security Exchange Name Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Current Reporting Status Entity Interactive Data Current Entity Interactive Data Current Entity Filer Category Entity Filer Category Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company ICFR Auditor Attestation Flag Entity Shell Company Entity Shell Company Entity Public Float Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Documents Incorporated by Reference [Text Block] Documents Incorporated By Reference Entity Central Index Key Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Amendment Flag Amendment Flag Auditor Name Auditor Firm ID Auditor Location Statement of Financial Position [Abstract] Assets [Abstract] Assets Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents Marketable Securities, Current Marketable securities Receivables, Net, Current Trade and royalty receivables, net Inventory, Net Inventory, net Total inventory Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Assets, Current Total current assets Property, Plant and Equipment, Net Fixed assets, net Property, Plant and Equipment, Net, Total Fixed assets, net Intangible Assets, Net (Excluding Goodwill) Intangible assets, net Goodwill Goodwill Operating Lease, Right-of-Use Asset Operating lease ROU assets Represents the carrying value of amounts transferred to third parties for security purposes and other noncurrent assets that are expected to be returned or applied towards payment after one year or beyond the operating cycle, if longer. Deposits and Other Assets Noncurrent Deposits and other assets Assets Total assets Total assets Liabilities and Equity [Abstract] Liabilities and stockholders' equity Liabilities, Current [Abstract] Current liabilities: Accounts Payable and Accrued Liabilities, Current Accounts payable and accrued expenses Accounts payable and accrued expenses Long-term Debt, Current Maturities Current portion of long-term debt Contract with Customer, Liability, Current Deferred revenue Operating Lease, Liability, Current Operating lease liabilities- current Finance Lease, Liability, Current Finance lease liabilities- current Amount of liabilities related to the sale of future royalties due within one year or the normal operating cycle, if longer. Liability, Sale of Future Royalties, Current Liability for sale of future royalties - current Other Liabilities, Current Other current liabilities Liabilities, Current Total current liabilities Long-term Debt, Excluding Current Maturities Long-term debt Business Combination, Contingent Consideration, Liability, Noncurrent Contingent consideration payable Deferred Income Tax Liabilities, Net Deferred tax liability Operating Lease, Liability, Noncurrent Operating lease liabilities- noncurrent Finance Lease, Liability, Noncurrent Finance lease liabilities- noncurrent Amount of liabilities related to the sale of future royalties due after one year or the normal operating cycle, if longer. Liability, Sale of Future Royalties, Noncurrent Liability for sale of future royalties- noncurrent Other Liabilities, Noncurrent Other long-term liabilities Liabilities Total liabilities Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Common Stock, Value, Issued Common stock, $0.001 par value. Authorized 250,000,000 shares; issued and outstanding 70,828,226 shares at December 31, 2021. Authorized 125,000,000 shares; issued and outstanding 69,718,096 shares at December 31, 2020 Additional Paid in Capital Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive loss Retained Earnings (Accumulated Deficit) Accumulated deficit Retained earnings (accumulated deficit) Stockholders' Equity Attributable to Parent Balance at the end of the period Balance at the beginning of the period Total stockholders' equity Stockholders equity Liabilities and Equity Total liabilities and stockholders' equity Common Stock, Par or Stated Value Per Share Common stock, par value (in dollars per share) Common Stock, Shares Authorized Common stock, authorized shares (in shares) Common Stock, Shares, Issued Common stock, issued shares (in shares) Common Stock, Shares, Outstanding Common stock, outstanding shares (in shares) Income Statement [Abstract] Statement [Table] Statement [Table] Product and Service [Axis] Product and Service [Domain] Net product revenue Grant And Collaboration [Member] Collaboration and grant revenue Collaboration revenue Royalty revenue Statement [Line Items] Statement [Line Items] Revenues [Abstract] Revenues: Revenue from Contract with Customer, Excluding Assessed Tax Revenue Operating Expenses [Abstract] Operating expenses: Cost of Goods and Service, Excluding Amortization Of Intangible Assets Cost of Goods and Service, Excluding Amortization Of Intangible Assets Cost of product sales, excluding amortization of acquired intangible assets Amortization of Intangible Assets Amortization of intangible assets Research and Development Expense Research and development Selling, General and Administrative Expense Selling, general and administrative Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Asset Change in the fair value of deferred and contingent consideration Settlement Of Deferred And Contingent Consideration Settlement Of Deferred And Contingent Consideration Settlement of deferred and contingent consideration Operating Expenses Total operating expenses Operating Income (Loss) Loss from operations Interest Income (Expense), Nonoperating, Net Interest expense, net Other Nonoperating Income (Expense) Other (expense) income, net Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Loss before income tax expense Income Tax Expense (Benefit) Income tax benefit (expense) Total tax benefit (expense) Net Income (Loss) Attributable to Parent Net loss Net loss attributable to common stockholders Weighted Average Number of Shares Outstanding, Diluted [Abstract] Weighted-average shares outstanding: Denominator Weighted Average Number of Shares Outstanding, Basic Basic Weighted Average Number of Shares Outstanding, Diluted Diluted Earnings Per Share [Abstract] Net loss per share-basic and diluted (in dollars per share) Earnings Per Share, Basic Basic Earnings Per Share, Diluted Diluted Statement of Comprehensive Income [Abstract] Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive (loss) income: Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Unrealized loss on marketable securities, net of tax of $0 Unrealized (loss) gain on marketable securities, net of tax Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent Foreign currency translation gain (loss), net of tax of $0 Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Other Comprehensive Income (Loss), Available-for-sale Securities, Tax, Portion Attributable to Parent Unrealized loss on marketable securities, tax Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Tax, Portion Attributable to Parent Foreign currency translation gain, tax Statement of Stockholders' Equity [Abstract] Equity Components [Axis] Equity Component [Domain] Common stock Additional paid-in capital AOCI Attributable to Parent Accumulated deficit Cumulative Effect, Period of Adoption [Axis] Cumulative Effect, Period of Adoption [Domain] Cumulative Effect Adjustment Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity Shares, Issued Balance (in shares) Balance (in shares) Adjustments to Additional Paid in Capital, Equity Component of Convertible Debt Equity component of convertible notes, net Stock Issued During Period, Shares, New Issues Issuance of common stock related to equity offering (in shares) Issuance of common stock related to equity offerings (in shares) Stock Issued During Period, Value, New Issues Issuance of common stock related to equity offering Stock Issued During Period, Shares, Acquisitions Issuance of common stock related to acquisition (in shares) Issuance of common stock related to acquisition (in shares) Stock Issued During Period, Value, Acquisitions Issuance of common stock related to acquisition Stock Issued During Period, Shares, Exchange Rights Stock Issued During Period, Shares, Exchange Rights Issuance of common stock related to rights exchange (in shares) Stock Issued During Period, Value, Exchange Rights Stock Issued During Period, Value, Exchange Rights Issuance of common stock related to rights exchange Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Exercised (in shares) Exercise of options (in shares) Stock Issued During Period, Value, Stock Options Exercised Exercise of options Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Restricted stock vesting and issuance (in shares) Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Restricted stock vesting and issuance, net Stock Issued During Period, Shares, Employee Stock Purchase Plans Issuance of common stock in connection with an employee stock purchase plan (in shares) Stock Issued During Period, Value, Employee Stock Purchase Plan Issuance of common stock in connection with an employee stock purchase plan APIC, Share-based Payment Arrangement, Increase for Cost Recognition Share-based compensation expense Adjustments to Additional Paid In Capital Receivable from Investor Adjustments to Additional Paid In Capital Receivable from Investor Receivable from investor Stockholders' Equity, Other Other Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Comprehensive income (loss) Statement of Cash Flows [Abstract] Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Cash flows from operating activities Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Depreciation, Depletion and Amortization Depreciation and amortization Operating Lease, Right-of-Use Asset, Amortization Expense Non-cash operating lease expense Finance Lease, Right-of-Use Asset, Amortization Non-cash finance lease amortization expense Amount of royalty revenue included in net income relating to sale of future royalties that results in no cash inflow (outflow). Noncash Royalty Revenue, Sale of Future Royalties Non-cash royalty revenue related to sale of future royalties Amount of interest expense included in net income relating to the liability for sale of future royalties that results in no cash flow. Noncash Interest Expense, Liability Related to Sale of Future Royalties Non-cash interest expense on liability related to sale of future royalties Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability Change in valuation of deferred and contingent consideration Shares issued Asset Acquisition Shares issued Asset Acquisition Non-cash stock consideration, acquisition Amount of unrealized gain (loss) on ClearPoint equity investment measured at fair value with change in fair value recognized in net income (FV-NI). ClearPoint Equity Investment, FvNi Unrealized Gain (Loss) Unrealized loss (gain) on ClearPoint Equity Investments Debt Securities, Available-for-sale, Unrealized Gain (Loss) Unrealized loss (gain) on ClearPoint convertible debt security Unrealized gain (loss) on convertible note Equity Securities, FV-NI, Unrealized Gain (Loss) Unrealized gain on marketable securities - equity investments Net unrealized gain (loss) on equity investments Accretion (Amortization) of Discounts and Premiums, Investments Amortization of premiums (discounts) on investments, net Amortization of Debt Issuance Costs Amortization of debt issuance costs Share-based Payment Arrangement, Noncash Expense Share-based compensation expense Paid-in-Kind Interest Non-cash interest expense Gain (Loss) on Disposition of Assets Disposal of asset Deferred Income Tax Expense (Benefit) Deferred income taxes Foreign Currency Transaction Gain (Loss), Unrealized Unrealized foreign currency transaction losses (gains), net Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Inventories Inventory, net Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other current assets Increase (Decrease) in Receivables Trade and royalty receivables, net Increase (Decrease) in Deposit Assets Deposits and other assets Increase (Decrease) in Accounts Payable and Accrued Liabilities Accounts payable and accrued expenses Increase (Decrease) in Other Operating Liabilities Other liabilities Increase (Decrease) in Contract with Customer, Liability Deferred revenue Net Cash Provided by (Used in) Operating Activities Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Cash flows from investing activities Payments to Acquire Property, Plant, and Equipment Purchases of fixed assets Payments To Acquire Convertible Debt Investment Payments To Acquire Convertible Debt Investment Purchase of convertible debt security Payments to Acquire Debt Securities, Available-for-sale Purchases of marketable securities - available for sale Purchase of convertible note Payments to Acquire Marketable Securities Purchases of marketable securities - equity investments Purchase of marketable securities - equity investments Proceeds from Sale of Debt Securities, Available-for-sale Sale and redemption of marketable securities- available for sale Proceeds from Sale and Maturity of Marketable Securities Sale and redemption of marketable securities - equity investments Redemption of marketable securities- equity investments Payments to Acquire Intangible Assets Acquisition of product rights and licenses Payments to Acquire Equity Method Investments Purchase of equity investment in ClearPoint Purchase of equity investment in ClearPoint Net Cash Provided by (Used in) Investing Activities Net cash provided by (used in) investing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Cash flows from financing activities Proceeds from Convertible Debt Proceeds from issuance of convertible notes Proceeds from Stock Options Exercised Proceeds from exercise of options Payment for Debt Extinguishment or Debt Prepayment Cost Termination and exit fees related to payoff of secured term loan Proceeds from Issuance of Common Stock Net proceeds from public offerings Repayments of Secured Debt Repayment of senior secured term loan Payments On Deferred Consideration Obligation Payments On Deferred Consideration Obligation Payments on deferred consideration obligation Payments on deferred consideration obligation Proceeds from Stock Plans Proceeds from employee stock purchase plan Payment of Finance Lease Principal Payment of Finance Lease Principal Payment of finance lease principal Cash received for sale of future royalties during the current period. Proceeds From Sale of Future Royalties Cash consideration received from Royalty Purchase Agreement Proceeds from sale of future royalties